氧自由基对大鼠急性出血坏死性胰腺炎并发脑组织损害的作用  

Effect of oxygen free redical on experimental rats with acute hemorrhagic necrotizing pancreatitis accompanied by damage of the brain tissue.

作　　者：赵海平[1,2] 王万祥[1,2] 欧阳晓晖[1,2] 刘淑平[1,2] 罗淑琴[1,2] 杨成旺[1,2] 寿乃延[1,2] 

机构地区：[1]内蒙古医学院附一院普外科 [2]内蒙古医学院基础部

出　　处：《肝胆胰外科杂志》1999年第2期77-78,共2页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的探讨大鼠急性出血坏死性胰腺炎（ＡＨＮＰ）过程中，氧自由基对大鼠脑组织的损害作用。方法通过大鼠胰胆管逆行５％牛磺胆酸钠注射诱发ＡＨＮＰ模型，检测６、１２、２４ｈ对照组及ＡＨＮＰ组大鼠脑组织ＰＬＡ２活性、丙二醛（ＭＤＡ）含量、超氧化物歧化酶（ＳＯＤ）活性及脑系数（ＢＩ），同步观察胰腺及脑组织学变化。结果ＡＨＮＰ组与对照组比较，脑组织ＰＬＡ２活性、ＭＤＡ含量及ＢＩ增加，ＳＯＤ活性降低，光镜下脑组织间质及细胞肿胀，髓鞘变性。结论大鼠ＡＨＮＰ并发脑组织损害；Objective To evaluate the effect of oxygen free redical rats with on experimental rats with acute hemorrhagic necrotizing pancreatitis(AHNP) with the damage of the brain tissue.Methods The rats were randomly divided into two groups:control group and AHNP group.AHNP with damage of the brain tissue was induced by retrograde injection of 5% sodium taurocholate into the common choledocho-pancreatic duct.Phospholipid enzyme A 2(PLA 2),Malondialdenhyde(MDA),scavengers superoxidedismutase(SOD) of the brain tissue and brain index(BI) were examined in control group and AHNP group.Results PLA 2,MDA and BI were increased and SOD was decreased in the brain tissue of AHNP group.Conclusion The experimental model of AHNP with damage of the brain tissue is ideal.PLA 2 and oxygen free redicals(OFR) participate in the occurrence and development of the brain tissue damage of AHNP.

关 键 词：急性 出血坏死性 胰腺炎 氧自由基 大鼠 

分 类 号：R657.510.2[医药卫生—外科学]