乌司他丁对多脏器功能障碍综合征的临床疗效观察  

作　　者：叶初阳[1] 刘延媛[1] 杨日焰[1] 石喆[1] 

机构地区：[1]惠州市中心人民医院,516000

出　　处：《中国实用医药》2010年第24期23-25,共3页China Practical Medicine

摘　　要：目的探讨乌司他丁(UTI)对多脏器功能障碍综合征(MODS)的治疗作用。方法将106例MODS患者随机分为UTI)治疗组和对照组,观察两组第1、10天血常规、CRP、肝肾功能及急性生理与慢性健康评估Ⅱ(APACHEⅡ)评分,并进行比较。结果与对照组比较,治疗组第10天WBC、ALT、总胆红索、肌酐、CRP、APACHElI评分降低、血小板升高,第21天病死率下降(P均<0.05)。结论乌司他丁治疗多脏器功能障碍综合征患者具有良好的临床效果。Objective To investigate the efficacy of Ulinastatin（ UTI） in patients with MODS.Methods 106 patients with MODS were randomly divided into UTI group（ n = 55） and control group（ n = 51） . In the group of UTI,patients had Ulinastatin 300000 IU three times every day for 10 days. Before treatment,on the tenth day after the treatment,blood samples were taken from peripheral veins for the determination of CRP、 WBC、PLT、ALT、TbiL、sCr、and simultaneously APACHEⅡ scores were recorded. Mortality rate was compared on 21th day. Results The indexes of two groups were similar before treatment. After the treatment,the levels of CRP、WBC、ALT、TbiL、sCr and APACHE Ⅱ scores were decreased in two groups after the treatment （ P 0. 05） ,but the decreases of all these plasma biochemistria indexes were more marked in UTI group（ P 0. 05） . The levels of PLT were increased in two groups after the treatment（ P 0. 05） ,but the increases of the levels of PLT were more marked in UTI group（ P 0. 05） . Conclusion UTI has beneficial effects in patients with MODS.

关 键 词：多脏器功能障碍 乌司他丁 临床疗效 

分 类 号：R459.7[医药卫生—急诊医学]