肝移植的免疫抑制治疗  

The immunosuppressive therapy of liver transplantation

作　　者：冯留顺[1] 张水军[1] 娄小平[1] 姜笑晨 于莉莉 

机构地区：[1]河南医科大学第一附属医院,郑州450052

出　　处：《河南医科大学学报》1999年第2期10-11,共2页Journal of Henan Medical University

基　　金：河南省科技攻关项目!951200301;河南省卫生厅重点科研项目!961047106

摘　　要：探讨肝移植术后免疫抑制治疗的方法。方法：对１例原发性肝细胞癌患者实施原位肝移植术， 术后应用强的松和标准剂量的环孢霉素Ａ进行免疫抑制治疗，对术后急性排斥反应使用甲基强的松龙冲击治疗， 根据血中环孢霉素 Ａ浓度调整用量。结果：患者术后第４ ｄ进少量流食，第 ７ ｄ下床活动，第 １３ ｄ肝穿病理示急性 排斥反应，经甲基强的松龙冲击治疗后逆转，术后８周回普通病房，术后３．５个月死于肺部感染。结论：术后应加 强急性排斥反应的监测，作出及时诊断和治疗，以利于肝移植患者的长期存活。To investigate the methods of the immunosuppressive treatment of the liver transplantation.Methods: Atriple-drug immunosuppressive protocol was used in a liver transplanataion with primary hepatic carcinoma.The episode of late acute rejection was treated with bolus dosage steroid,and the dose of Cyclosporine A(CsA)was regulated according to its concentration in blood .Results:The patient could eat a littel liqual food in the 4th day post operation(pod),move freely 7 pod,needle biopsy confirmed acute rejection (AR)13pod,Bolus dosage methylprednisolone reversed AR,8weeks after the operation the patient lived in ordinary ward and died of pneumonia 3.5 months after the operation.Conclusion:The monitoring of immunologic rejection should be strenthened after liver transplantation.The diagnosis and treament should be accomplished at once.

关 键 词：肝移植 排斥 环孢霉素A 甲基强的松龙 

分 类 号：R657.305[医药卫生—外科学]