5-氟水杨醛的制备  

Preparation of 5-Fluorosalicylaldehyde

作　　者：汪硕鳌[1] 陈红飙[1] 申理滔[1] 林原斌[1] 

机构地区：[1]湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105

出　　处：《中国医药工业杂志》2010年第8期564-565,共2页Chinese Journal of Pharmaceuticals

基　　金：湖南省教育厅资助项目(03C461)

摘　　要：对硝基氯苯经氟代、氯化铵/铁粉还原制得对氟苯胺,重氮化后酸性水解所得对氟苯酚,再经改进的Duff甲酰化制得5-氟水杨醛,总收率约23%。5-Fluorosalicylaldehyde was synthesized from 4-nitrochlorobenzene by fluorination and reduction with NH4Cl/Fe to give 4-fluoroaniline,which was subjected to diazotization and hydrolysis to form 4-fluorophenol,followed by Duff formylation with an overall yield of about 23%.

关 键 词：5-氟水杨醛 中间体 制备 

分 类 号：O625.21[理学—有机化学]