脱氢枞胺衍生物Schiff碱的合成及其抗肿瘤活性  

Synthesis and Antitumor Activities of Schiff's Bases of Dehydroabietylamine Derivative

作　　者：张曙光[1] 林中祥[1] 

机构地区：[1]南京林业大学化学工程学院,江苏南京210037

出　　处：《中国医药工业杂志》2010年第8期566-568,579,共4页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金(30771688)

摘　　要：脱氢枞胺经乙酰化、硝化、还原制得12-氨基-N-乙酰脱氢枞胺,再与相应的取代苯甲醛反应制得一系列脱氢枞胺衍生物的Schiff碱6a～6e。选用Hey-1B卵巢癌细胞株测定了目标物的体外抗肿瘤活性,结果显示6a～6e体外对Hey-1B卵巢癌细胞株均有一定活性。Dehydroabietylamine underwent acetylation,nitration and reduction to give 12-aminoN-acetyldehydroabietylamine,which reacted with substituted benzaldehydes to obtain five Schiff＇s bases of dehydroabietylamine derivative（6a～6e）.Their antitumor activities on Hey-1B ovarian cancer cell line were tested.The results showed that 6a～6e had inhibitory effects on Hey-1B ovarian cancer cell line in vitro.

关 键 词：脱氢枞胺 衍生物 SCHIFF碱 合成 抗肿瘤活性 

分 类 号：R979.1[医药卫生—药品]