聚合物胶束在肿瘤治疗中的研究进展  

Progress of Polymeric Micelles for Cancer Therapy

作　　者：李远达[1] 朱亮[1] 

机构地区：[1]广东药学院药剂学教研室,广东广州510006

出　　处：《中国医药工业杂志》2010年第8期615-621,共7页Chinese Journal of Pharmaceuticals

摘　　要：聚合物胶束在肿瘤治疗方面具有高效、长效及高载药量等优势。本文简单比较了聚合物胶束与其它纳米级药物载体(如高分子直接键合药物、树枝状聚合物、脂质体)在临床应用上的优缺点。综述了聚合物胶束在肿瘤主动靶向性、环境刺激响应释药及医学成像等方面的研究进展。Polymeric micelles have many considerable advantages of high eff iciency,long-acting and high drugloading in cancer therapy.The advantages and disadvantages of polymeric micells in clinical application are compared with other nanocarriers such as polymer-drug conjugates,dendrimers and liposomes.The progress of polymeric micells in the fields of active tumor targeting,environmental stimulus-sponsive drug release and medical imaging is reviewed.

关 键 词：聚合物胶束 肿瘤治疗 纳米载体 综述 

分 类 号：R944.9[医药卫生—药剂学]