壳聚糖交联温敏性水凝胶的制备与性能  

Synthesis and Characterization of Hydrogels Cross-Linked by N-Maleyl Chitosan(N-MACH)

作　　者：于跃芹[1] 许洋[1] 李延顺[1] 

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042

出　　处：《高分子材料科学与工程》2010年第7期133-135,139,共4页Polymer Materials Science & Engineering

基　　金：山东省自然科学基金资助项目(Y2006B10);青岛市科技计划基础研究项目资助项目(09-1-3-33-JCH)

摘　　要：利用N-马来酰化壳聚糖(N-MACH)为交联剂,以N-异丙基丙烯酰胺(NIPAAm)、衣康酸(IA)为单体,利用水溶液自由基聚合反应合成了P(NIPAAm-co-IA)水凝胶。研究了水凝胶的相转变性质、低临界溶解温度(LCST)和溶胀性能。该类水凝胶在32℃左右具有明显的相转变特性,其LCST随衣康酸用量的增加而增大,交联剂的用量对水凝胶的LC-ST值无显著影响。水凝胶的溶胀性能具有较为明显的温度依赖性和介质依赖性,其饱和溶胀度与NIPAAm/IA的比例、交联密度及溶胀介质有关。With N-maleyl chitosan（N-MACH） cross-linker, a series of cross-linked poly（N-isopropylacrylamide-co-itaconic acid） [P（NIPAAm-co-IA）]hydrogels were prepared, and their phase transition behavior, lower critical solution temperature （LCST）, water content were investigated. The hydrogels have a reversible hydrophilic/hydrophobic phase transition at the LCST of approximately 32 ℃. The LCST of N-MACH-cross-linked P（NIPAAm-co-IA） hydrogels is significantly influenced by mass ratio of the NIPAAm/IA, but it is not influenced by cross-linking density within the polymer network. Swelling depends on the swelling media and temperature. At 25 ℃ and 37 ℃, the water content of N-MACH-cross-linked P（NIPAAm-co-IA） hydrogels is controlled by the mass molar ratio of NIPAAm/IA, the cross-linking density and swelling media.

关 键 词：N-马来酰化壳聚糖 P(NIPAAm-co-IA)水凝胶 温敏性 溶胀性能 

分 类 号：TB381[一般工业技术—材料科学与工程]