促甲状腺激素、甲状腺过氧化物酶抗体和促甲状腺激素受体抗体检测在甲状腺疾病中的应用价值  

The Value of Determination of Serum TSH,TPOAb and TRAb in Patients with Thyroid Diseases

作　　者：朱利国[1] 浦洪波[1] 武红玉[1] 李跃松[1] 陈永伟[1] 

机构地区：[1]江苏省原子医学研究所附属江原医院,江苏无锡214063

出　　处：《标记免疫分析与临床》2010年第4期241-243,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺激素受体抗体(TRAb)在甲状腺疾病中的诊断价值。对44例Graves病(GD)、29例桥本甲状腺炎(HT)、13例亚甲炎患者和26例正常对照,采用电化学发光免疫分析法测定TSH、TPOAb、TRAb的含量,分析其在几组病例中的意义。三病例组的TSH、TPOAb、TRAb含量与正常对照组比均有显著差异(P<0.01);HT组TPOAb的测值和阳性率又显著高于GD组,而GD组TRAb的测值和阳性率都显著高于HT组,经统计学检验两者均有显著意义(P<0.05)。结果说明,TSH是甲状腺功能的非常敏感的特异性参数,TPOAb、TRAb的检测对鉴别诊断GD和HT有着重要意义。To explore the value of measurement of thyroid-stimulating hormone（TSH）,thyroid peroxidase antibody（TPOAb） and thyroid-stimulating hormone receptor antibody（TRAb） in Hypothyroid Disease.The serum levels of TSH,TPOAb and TRAb in 44 cases of Graves,Disease（GD）,29 cases of Hashimoto＇s thyroidities（HT）,26 cases of subacute thyroiditis and 26 normal controls were measured by ECLIA.The results showed that the serum levels of TSH,TPOAb and TRAb in all patients were significant higher than that of normal controls（P0.01）.The serum levels and positive rates of TPOAb in patients with HT were significantly higher than those in GD;the serum levels and positive rates of TRAb in patients with GD were significantly higher than those in HT（P0.05）.The serum TSH is very sensitive and special parameter of the function of the hypothyroidism.The comprehensive analysis of TPOAb and TRAb might be helpful in the differential diagnosis between GD and HT.

关 键 词：GRAVES病 桥本甲状腺炎 促甲状腺激素 甲状腺过氧化物酶抗体 促甲状腺激素受体抗体 

分 类 号：R581[医药卫生—内分泌]