金属硫蛋白与镉中毒性肝肾损害的关系  

Relationship Between Metallothionein and Cadmium-Induced Liver and Kidney Injury

作　　者：龙建勋 贺全仁[1,2] 王翔朴 

机构地区：[1]湖南省长沙市职业病防治所 [2]湖南医科大学毒理学教研室

出　　处：《实用预防医学》1999年第3期177-179,共3页Practical Preventive Medicine

摘　　要：目的观察亚慢性镉中毒性肝肾损害，并初步探讨金属硫蛋白（ＭＴ）与肝肾损害的关系。方法用Ｗｉｓｔａｒ大鼠腹腔注射０．５ｍｇ／ｋｇＣｄ２＋的ＣｄＣｌ２３次／周，共１０周，染毒后不同时期处死大鼠，观察肝肾功能变化。结果染毒６周后，大鼠出现了明显的肝肾损害，相应组织中Ｃｄ∶ＭＴ的摩尔数之比均超过７，且随染毒总剂量的增加，Ｃｄ∶ＭＴ值明显增加，病变程度加重。结论肝肾是亚慢性镉中毒的靶器官，非ＭＴ结合的镉可能是损害肝、肾的主要成分。Objective To observe subchronic cadmium-induced liver and kidney injury,and to study the relationship between Metallothionein(MT)and cadmium toxicity. Methods 0.5mg/kg Cd2+ as CdCl2 solution was injected intraperitoneally,3 times/week,and the functions of liver and kidney were detected dynamically in 10 weeks of cadmium exposure. Results After 6-week cadmium exposure,the injury of liver and kidney was observed functionally and morphologically,and the mole ratio of Cd over MT in corresponding tissue was greater than 7. The severity of cadmium-induced damage increased with the increase of CdMT ratio. Conclusion Both liver and kidney are targets of subchronic cadmium exposure,and non-MT-bound cadmium may be an important component in cadmium pathogenesis.

关 键 词：镉 肝脏 肾脏 金属硫蛋白 镉中毒 

分 类 号：R994.3[医药卫生—毒理学] R992[医药卫生—药学]