昆虫醛氧化酶研究进展  

Research Progress in Insect Aldehyde Oxidase

作　　者：杨从文[1] 杨瑜[1] 王艳霞[1] 费纪涛[1] 林英[1] 

机构地区：[1]西南大学,农业部蚕桑功能基因组与生物技术重点开放实验室,重庆400716

出　　处：《蚕业科学》2010年第4期656-666,共11页ACTA SERICOLOGICA SINICA

基　　金：国家教育部"长江学者和创新团队发展计划"项目(No.IRT0750);国家重点基础研究发展计划"973"项目(No.2005CB121000);国家自然科学基金项目(No.30972147)

摘　　要：醛氧化酶(aldehyde oxidase,AO;EC1.2.3.1)是钼-黄素酶家族(molybdo-flavoenzyme family,MFE)中的一类蛋白,通常是由2个相同亚基形成的同源二聚体构成,每个亚基具有2个[2Fe-2S]氧化还原中心、1个黄素辅因子(FAD)和1个底物结合域,与钼-黄素酶家族的另一成员黄嘌呤氧化还原酶结构特征相似。AO可氧化醛类物质和将含氮杂环物质羟基化,在机体代谢过程中的作用至关重要。对醛氧化酶的结构、催化反应机制、系统进化等研究结果进行了综述,重点介绍了昆虫醛氧化酶的研究进展。Aldehyde oxidases （AO,EC1.2.3.1） are a group of proteins which belong to molybdo-flavoenzyme family （MFE）.They usually consist of a homodimer with two identical subunits,each of which has two [2Fe-2S]redox-active centers,one flavin cofactor and one substrate binding domain.These structural features are similar to xanthine oxidation-reductases,another member of the MFE family.AO exhibits oxidation activity towards aldehydes and hydroxylation activity towards N-heterocyclic compounds.It plays an important role in many metabolic processes of organisms.In this review,research progress in the structure,reaction mechanism,and phylogenesis of aldehyde oxidases was summarized with special emphasis on the progress obtained in insect.

关 键 词：昆虫醛氧化酶 结构 催化反应机制 系统发生 

分 类 号：Q966[生物学—昆虫学]