经典恒温恒湿法评价湿度和温度对阿莫西林稳定性的影响  

Evaluation of the influence of humidity and temperature on the stability of Amoxicillin by classical isothermal experiments

作　　者：韩雪[1] 封家福[2] 李琳丽[1] 蒙明程[1] 詹先成[1] 李成容[1] 饶永平[1] 魏晓婷[1] 

机构地区：[1]四川大学华西药学院靶向药物与释药系统教育部重点实验室,四川成都610041 [2]河南中医学院,河南郑州450008

出　　处：《华西药学杂志》2010年第4期436-437,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:30171117)

摘　　要：目的研究固体阿莫西林的降解动力学规律。方法采用HPLC法测定阿莫西林的含量;在恒温恒湿条件下进行加速试验,以获得与温度、湿度相关的动力学参数。结果阿莫西林遵从一级降解动力学规律;速率常数k=Aexp(-Ea/RT)·exp(mHr),指前因子A=(1.28±0.46)×1019h-1,活化能Ea=158.0%±1.01%kJ·mol-1,常数m=6.61%±0.05%。结论采用经典恒温恒湿法能研究温度和湿度对固体阿莫西林稳定性的影响。OBJECTIVE To perform a kinetic analysis of the degradation of Amoxicillin in the solid phase at different temperatures and relative humidities.METHODS Amoxicillin was incubated in an environmental chamber at different temperatures and relative humidities.After the incubation,the content of Amoxicillin in the presence of its degradation products was measured by HPLC.RESULTS The degradation rate of Amoxicillin obeyed first-order kinetics.The rate constant k could be expressed as：k = Aexp（-Ea /RT）·exp（mHr）,where the pre-exponential factor A was（1.28 ±0.37） ×10^19 h^-1.The observed activation energy Ea was 158.0% ± 1.01% kJ·mol^-1 and the constant m was 6.61% ± 0.05%.CONCLUSION The classical isothermal experiments at constant humidity can be used to investigate the stability of Amoxicillin in both moisture and heat.

关 键 词：阿莫西林 稳定性 温度 相对湿度 降解动力学 高效液相色谱法 

分 类 号：R913[医药卫生—药学]