冠心病、高脂血症和低高密度脂蛋白血症患者载脂蛋白Al基因的多态性  

POLYMORPHISM OF APOLIPOPROTEIN AI GENE IN CORONARY HEART DISEASE,HYPERLIPIDAEMIA AND HYPOALPHALIPOPROTEINEMIA PATIENTS

作　　者：严建[1] 陈灏珠[1] 宋后燕[2] 林佑善[1] 韩琴琴[1] 

机构地区：[1]上海医科大学中山医院上海市心血管病研究所 [2]上海医科大学中山医院分子遗传学研究所

出　　处：《上海医科大学学报》1990年第4期256-260,共5页Journal of Fudan University(Medical Science)

基　　金：国家自然科学基金1989准字第(3880412)

摘　　要：本实验用分析基因限制性内切酶片段长度多态性(Restriction fragment length olymorphisms,RFLPs)技术,检测到中国人载脂蛋白AI(Apolipoprotein AI。Apo AI)基因3′端存一PstI多态位点,并发现该多态位点与低高密度脂蛋白(HDL)血症及冠心病有较密切的关系。Using restriction fragment length polymorphisms (RFLPs) technique, we have detected a Pst I polymorphic site which is at the 3' end of apolipoprptein AI (Apo AI) gene in Chinese. In the population studied, significant differences in allele frequency were observed between subjects suffering from coronary heart disease, hypoalpha-lipoproteinemia and controls.

关 键 词：载脂蛋白 AI基因 冠心病 高血脂病 

分 类 号：R541.402[医药卫生—心血管疾病]