夹竹桃甙对Na^+、K^+-ATP酶抑制的动力学研究  

KINETIC STUDIES ON OLEANDRIN INHIBITION OF Na^+, K^+-ATPase

作　　者：潘彬[1] 陈锐群[1] 潘德济 顾天爵[1] 

机构地区：[1]上海医科大学基础医学部生物化学教研室 [2]药学院天然药物化学教研室

出　　处：《上海医科大学学报》1990年第6期413-417,共5页Journal of Fudan University(Medical Science)

摘　　要：本文对夹竹桃甙抑制Na^+、K^+-ATP酶的动力学作了探讨,并与乌本甙的作用进行了比较。结果表明:夹竹桃甙抑制Na^+、K^+-ATP酶,在Na^+、K^+浓度改变对均为非竞争性抑制,Na^+/K^+比例6:1时,为混合性抑制,而ATP对夹竹桃甙的作用几无影响。The kinetics and mechanism of inhibition of Na+, K+-ATPase by oleandrin were studied. Characteristics of its inhibitory action on Na+, K+-ATPase were compared with those of onabain. Kinetic analysis revealed oleandrin to be a non-competitive inhibitor with respect to Na+, K+, and showed mixed inhibition with respect to Na+/K+(6:1). ATP was without affect on oleandrininhibition of Na+, K+-ATPase.

关 键 词：夹竹桃甙 抑制剂 ATP酶 

分 类 号：R972.1[医药卫生—药品]