内毒素性休克时血浆纤维连接蛋白与微血管通透性的关系  

PLASMA FIBRONECTIN AND MICROVASCULAR PERMEABILITY IN ENDOTOXIC SHOCK RABBITS

作　　者：金惠铭[1] 陈达信[1] 闫友珍 

机构地区：[1]上海医科大学基础医学部病理生理学教研室

出　　处：《上海医科大学学报》1990年第6期401-404,共4页Journal of Fudan University(Medical Science)

基　　金：卫生部科学基金(编号87Y073)

摘　　要：用异硫氰酸荧光素右旋糖酐-150作示踪剂,观察内毒素性休克时兔和大鼠微血管通透性变化。结果发现,内毒素性休克兔微血管通透性随休克进展进行性升高,血浆纤维连接蛋白(Fn)含量随之下降,两者呈显著相关(P<0.05)。在内毒素性休克大鼠中补充纯化大鼠Fn后,血浆Fn恢复,在静脉补充后2h内,微血管通透性升高受明显抑制,但2h后作用消失。与对照组(补充缺乏大鼠Fn血浆的内毒素性休克大鼠)相比,治疗组(补充纯化大鼠Fn)内毒素性休克大鼠的存活时间并无明显延长。With FD-150 as a tracer, miorovasoular permeability was observed in 13 endo-toxie shook rabbits. The results showed that miorovasoular permeability increased while the content of plasma fibronectin (Pn) declined progressively during endoto-xio shook. There was a marked ocrrelation (P<0.05) between them. After infusion of purified rat Fn the content of plasma Fn returned almost to normal in these shocked rats. The increased miorovascular permeability was inhibited within 2 hours, but disappeared thereafter. There was no significant difference in survival time between treated rats (infusion of purified Fn) and control rats (infusion of Fn-deficient plasma). The significance of these results was briefly discussed.

关 键 词：内毒素休克 纤维连接蛋白 

分 类 号：R631.4[医药卫生—外科学]