依托泊苷壳聚糖-海藻酸钠微球的体内抗癌活性及在小鼠体内分布  

Inhibiting Lewis Tumor and Distribution of Lung Targeting Etoposide Chitosan-alginate Microsphere in Vivo in Mice

作　　者：杨建玲[1] 刘彦雪[2] 胡志成[3] 

机构地区：[1]河北省保定市儿童医院药剂科,河北保定071000 [2]河北大学附属医院手术室,河北保定071000 [3]河北省保定市儿童医院外科,河北保定071000

出　　处：《中国现代医生》2010年第24期10-11,共2页China Modern Doctor

摘　　要：目的研究制备的依托泊苷壳聚糖-海藻酸钠微球(Etoposide Chitosan-alginate Microsphere,ECAM)的体内抑瘤作用及体内分布。方法通过比较各组小鼠移植性Lewis肺癌的抑瘤率,考察含药微球的抑瘤效果;用高效液相色谱法测定各组织中依托泊苷浓度。结果依托泊苷微球抑瘤率为63.62%,明显高于其他各组;小鼠尾静脉注射微球后15min,肺内依托泊苷量占注入总量的(52.64±1.79)%。结论 ECAM具有明显的抑制移植性Lewis肺癌的作用和肺靶向效果。Objective To study the inhibiting Lewis tumor growth and distribution of etoposide Chitosan-alginate Microsphere in vivo in mice. Methods The anti-tumor effect of drug-containing microspheres was studied by comparing each group of mice transplanted Lewis lung cancer inhibition rate;The drug concent rations in various tissues were determined by high performance liquid chromatograph （HPLC）. Results Etoposide microspheres inhibition rate was 63-52%,significantly higher than other groups.The ECAM was injected into mice and （52.64 ± 1.79）% of the total dosage was detected in lung tissue after 15rain from administration. Conclusion The ECAM showed obvious inhibition of transplanted Lewis lung cancer and remarkable targeting action to the lung.

关 键 词：依托泊苷壳聚糖-海藻酸钠微球 肺靶向 体内分布 HPLC 

分 类 号：R979.1[医药卫生—药品]