年龄和内膜准备法对冻融胚胎移植妊娠率的影响  

Effect of Age and Method of Preparing Endometrium on the Pregnancy Rate of Frozen-Thawed Embryo Transfer in Treatment of Infertility

作　　者：贺贞[1] 朱明辉[1] 杨丹[1] 

机构地区：[1]成都中医药大学第二临床医学院第二附属医院生殖中心,成都610041

出　　处：《华西医学》2010年第7期1310-1312,共3页West China Medical Journal

摘　　要：目的探讨不同年龄段和不同内膜准备方法对冻融胚胎移植(FET)妊娠率的影响。方法回顾性分析2007年3月-2009年8月107例患者131个FET周期,比较不同年龄段、不同内膜准备方法的妊娠情况。结果①<29岁、30～34岁、≥35岁患者的周期临床妊娠率分别为45.28%、37.88%、33.33%,比较无统计学意义(P>0.05)。②自然周期和激素替代周期内膜准备,两种方法患者平均年龄、平均移植胚胎数、胚胎评分及胚胎细胞数比较无统计学意义(P>0.05),但自然周期的胚胎种植率及周期临床妊娠率均明显低于激素替代周期(16.78%比29.21%;29.51%比50.00%),比较有统计学意义(P<0.05)。结论患者年龄不影响FET周期临床妊娠率,激素替代周期内膜准备的FET胚胎种植率及周期临床妊娠率明显高于自然周期。Objective To analyze the effect of age and method of preparing endometrium on the pregnancy rate of frozen-thawed embryo transfer （FET） among infertile women.Methods Retrospective analysis was made on 131 FET cycles in 107 patients from March 2007 to August 2009.The relationship between pregnancy rate of FET and following factors were analyzed：age,the method of preparing uterus endometrium.Results ①There was no significant difference in pregnancy rate of FET among29,30-34,and ≥35 years old patients （45.28% ,37.88% ,and 33.33% ,respectively） （P0.05）.②There was no significant difference in patients＇age,the average embryo amount,embryo score,the cell amount in every embryo between the FET with hormone replacement therapy （HRT） and the FET with natural cycle （NC）.The embryo implantation rate and pregnancy rate of FET with NC were lower significantly than those of FET with HRT （16.78% vs 29.21% ; 29.51% vs 50.00% ） （P0.05）.Conclusion Age might not influence pregnancy rate of FET.FET with HRT has higher implantation rate and pregnancy rate than FET with NC.

关 键 词：冻融胚胎移植 自然周期 激素替代周期 临床妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]