109个体外受精胚胎移植周期行部分ICSI受精结局分析  

Fertilization rates following 109 half intracytoplasmic sperm injection cycles for in vitro fertilization-embryo transfer

作　　者：郭新宇[1] 张金玉[1] 林德伟[1] 于妍[1] 葛明晓[1] 

机构地区：[1]广州军区总医院妇产科辅助生育中心,广东广州510010

出　　处：《南方医科大学学报》2010年第8期1920-1922,共3页Journal of Southern Medical University

摘　　要：目的通过对109个体外受精胚胎移植（IVF-ET）周期行部分ICSI受精情况的分析,探讨对于潜在受精障碍患者合适的受精方式。方法回顾性分析109个体外受精胚胎移植周期中行部分ICSI的成熟卵母细胞共1850个,按可能存在受精障碍的原因分为5组：A组不明原因不孕患者,共17个周期;B组少弱精患者,受精前前向运动精子密度（35）×106/ml,共28个周期;C组畸精症患者,畸形精子百分率大于95%,共8个周期;D组无明确病因原发不孕患者,共31个周期;E组无明确病因继发不孕患者,共25个周期。比较各组中IVF与ICSI受精方式受精率的差异。结果 A组与D组ICSI受精率分别为（72.2±34.1）%和（82.7±21.4）%,均高于相应的IVF受精率[分别为（53.1±38.8）%,（58.8±31.6）%]（P〈0.05）;B组、C组与E组ICSI与IVF受精率无统计学差异（P〉0.05）;A组、B组、D组与E组ICSI正常受精率均高于IVF（P〈0.05）,C组ICSI与IVF正常受精率无统计学差异（P〉0.05）。结论不明原因不孕患者与无明确病因原发不孕患者行部分ICSI可改善IVF受精率,而少弱精、畸精症及无明确病因继发不孕患者行部分ICSI未能改善IVF受精率,提示对于以上患者行ICSI受精是否必要。Objective To evaluate the clinical outcomes of half intracytoplamic sperm injection （partial ICSI） treatment in infertile patients with potential fertilization failure. Methods A total of 109 partial ICSI cycles of in vitro fertilization-embryo transfer （IVF-ET） were classified into 5 groups, namely group A （infertile patients for unidentified causes, 17 cycles）, group B （oligo-asthenozoospermia patients, 28 cycles）, group C （teratozoospermia patients, 8 cycles）, group D （primary infertile patients without definite causes, 31 cycles）, and group E （secondary infertile patients without definite causes, 25 cycles）. The fertilization rate and normal fertilization rate after IVF and ICSI were compared between the groups. Results Significant differences were found in the fertilization rate following conventional IVF and ICSI in group A （53.1±38.8% vs 72.2±34.1%） and group D （58.8±31.6% vs 82.7±21.4%） （P〈0.05）, but not in groups B, C and E （P〉0.05）. The normal fertilization rates following IVF and ICSI in groups A, B, D, E were statistically different （P〈0.05）, but similar in group C （P〉0.05）. Conclusion ICSI treatment may increase the fertilization rate of IVF-ET in patients with unexplained infertility and primary infertility, but not in patients with oligo-asthenozoospermia, teratozoospermmia or secondary infertility.

关 键 词：移植 体外受精胚胎 部分ICSI 受精率 

分 类 号：R698.2[医药卫生—泌尿科学] R711.6[医药卫生—外科学]