慢性HBV感染者血清HBVDNA载量与HBeAg／抗-HBe、ALT之间的关系  

The caenaton among HBV DNA load, HBeAg/Anti-HBe and Alanine Aminotransferase in patients with chronic hepatitis B infection

作　　者：徐军[1] 王芳[1] 杨帆[1] 

机构地区：[1]淮南市第一人民医院检验科,安徽省淮南232007

出　　处：《中国基层医药》2010年第14期1877-1878,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨慢性HBV感染者血清HBVDNA载量与HBeAg／抗-HBe以及丙氨酸转氨酶（ALT）水平之间的关系。方法采用酶联免疫吸附法（ELISA）检测134例慢性HBV感染者HBV血清标志物，根据HBeAg／抗-HBe检测结果将患者分为Ⅰ组（HBeAg＋／抗-HBe-，43例）；11组（HBeAg-／抗-HBe＋，69例）；Ⅲ组（HBeAg-／抗-Hbe-，22例）。同时应用实时荧光定量PCR方法以及连续监测法检HBVDNA载量以及ALT水平。结果Ⅰ组HBVDNA阳性率和HBVDNA载量明显高于Ⅱ、Ⅲ组（P〈0．01）。HBVDNA阳性患者ALT异常率高于HBVDNA阴性患者（P〈0．01）。HBVDNA阳性患者HBVDNA载量与ALT水平之间无相关性（r=0．174，P=0．156）。结论血清HBVDNA载量与HBeAg／抗-HBe以及ALT之间存在一定的关系，但不能单纯依靠HBeAg／抗-HBe以及ALT来判断HBV在体内的复制情况，三项指标联合检测对HBV慢性感染者的病情检测、治疗具有重要意义。Objective To explore the relationship among HBV DNA load, HBeAg/Anti-HBe and ALT in patients with chronic hepatitis B infection. Methods HBV markers in 134 patients with chronic HBV infection were detected by FLISA, and patients were divided into group  （HBeAg ＋/Anti-HBe-,43 patients） , group Ⅱ （HBeAg-/Anti- HBe ＋ ,69 patients） and group Ⅲ（ HBeAg-/Anti-Hbe-,22 patients） according to the results of presence of HBeAg/ Anti-IIBe. HBV DNA load and ALT were tested respectively by fluorescence quantitative polymerase chain reaction successive monitor reaction. Results Both the positive rate and the HBV DNA load quantification in group Ⅰ were higher than in group Ⅱ and Ⅲ（ P 〈 0. 01 ）. Abnormality rate of ALT in HBV DNA positive patients was higher than the patients with HBV DNA negitive（ P 〈 0.01 ）. There was no relationship between HBV DNA load and ALT in HBV DNA positive patients. Conclusion There was a certain corelation among HBV DNA load, HBeAg/An-ti-HBe and ALT,but the active degree of HBV replication could not to be assessed by HBeAg/Anti-HBe or ALT alone. It was necessary for the padient with chronic HBV infection to examine them together.

关 键 词：乙型肝炎 慢性 HBV DNA载量 HBeAg/抗-HBe ALT 

分 类 号：R4[医药卫生—临床医学] R51