太子参多糖对糖尿病大鼠降糖作用机制的研究  

The mechanism of Pseudostellaria Polysaccharides decreasing leptin level on Diabetic Rats

作　　者：居靖[1] 夏伦祝[2] 徐先祥[1] 

机构地区：[1]安庆市立医院药剂科,安徽省安庆246003 [2]安徽中医学院第一附院药学部

出　　处：《中国基层医药》2010年第14期1909-1910,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究太子参多糖对实验性糖尿病大鼠降糖作用机制。方法糖尿病模型采用大鼠腹腔注射四氧嘧啶200mg／kg制作，观察太子参多糖不同剂量对糖尿病模型大鼠消脂素和肿瘤坏死因子-α的影响。结果中、高剂量太子参多糖（0．6g／kg，1．2g／kg）能显著升高糖尿病大鼠血清消脂素水平，同时能降低糖尿病大鼠血清肿瘤坏死因子-α水平（P〈0．05或P〈0．01）。结论太子参多糖能通过多个途径发挥对实验性糖尿病大鼠的治疗作用。Objective To investigate potential mechanism of decreasiy leptin level of Pseudostellaria Poly- saccharides on experimental diabetic rats. Methods The diabetic rats were induced by the abdominal cavity injection of alloxen（ALX） 200 mg·kg-1. The levels of leption and TNF-α were determined. Results Pseudostellaria Polysaccharides （0.6 g· kg-1, 1.2 g ·kg-1 ）could increase Leptin level and could decrease TNF-α level of DM rats （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion Pseudostellaria Polysaeeharldes can play an threpedtie rale in the experiment aldialetic rats through multi-pathway the experimental diabetic rats.

关 键 词：太子参多糖 糖尿病大鼠 肿瘤坏死因子-Α 消脂素 

分 类 号：R28[医药卫生—中药学]