体外应用己酮可可碱和2-脱氧腺苷提高冷冻复温后精液质量的研究  

Study on the improvement of the quality of the frozen and defrozen sperms by pentoxifylline and 2 deoxyadenosine in vitro

作　　者：刘忠国[1] 李冰清[2] 申东亮[2] 王沛涛[3] 崔向东[3] 刘金刚[3] 

机构地区：[1]滨州医学院附属医院泌尿外科 [2]青岛医学院附属医院泌尿外科 [3]青岛医学院附属医院低温医学科

出　　处：《中国男科学杂志》1999年第2期85-89,共5页Chinese Journal of Andrology

摘　　要：本文在光学显微镜下观察和测定了己酮可可碱和２脱氧腺苷在体外对冷冻复温后精液精子的活率、活力及其毛细管穿透值的影响。结果：两者均能提高上述三项参数。其最适浓度分别为４．０ｍｍｏｌ／Ｌ、２．０ｍｍｏｌ／Ｌ，与对照组比较均有显著性差异（Ｐ＜０．０１）。两组间比较，２脱氧腺苷优于己酮可可碱（Ｐ＜０．０１）。The effects of pentoxifulline(PF) and 2 deoxyadenosine (2 DA) on the sperm viability,motility and the sperm glass capillary penetration were assayed under light microscope after incubation with the frozen and defrozen sperms in vitro.Results:Both PF and 2 DA could improve the sperm viablity,the motility and the sperm glass capillary penetration value.Their optimal concentration were 4.0 mmol/L and 2.0 mmol/L respectively (Compared with control, P <0.01).The effects of 2 DA were better than that of PF ( P <0.01).

关 键 词：己酮可可碱 2-脱氧腺苷 冷冻复温 精子 

分 类 号：R321－33[医药卫生—人体解剖和组织胚胎学]