胎盘免疫调节肽联合化疗药物抗肿瘤作用的研究  

Antitumor Effects of the Placental Immunoregulating Polypeptide Combining with Chemotherapeutic Drugs

作　　者：丰慧根[1] 任太芳[2] 韩金红[1] 李延兰[1] 杨保胜[1] 

机构地区：[1]新乡医学院细胞生物学教研室,453003 [2]新乡医学院第一附属医院

出　　处：《中国生化药物杂志》1999年第3期129-131,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：河南省自然科学基金

摘　　要：探讨胎盘免疫调节肽（ＰＩＰ）联合化疗药物对肿瘤细胞的影响。方法：ＰＩＰ联合化疗药物一方面在体外与Ｓ_（１８０）和Ｋ５６２细胞接触；另一方面作用于接种Ｓ_（１８０）和ＦＣ瘤细胞的小鼠，同时观察对肿瘤细胞增殖的影响及小鼠肿瘤重量和转移结节数。结果：ＰＩＰ与化疗药物联合作用明显抑制Ｓ_（１８０）和Ｋ５６２细胞的增殖。体内实验结果显示；环磷酰胺单独使用的抑瘤率和转移率为２３．７％和２０％，与ＰＩＰ联合作用为５８％和６，７％。结论：ＰＩＰ与化疗药物有明显的协同作用，对肿瘤细胞有明显抑制效应。Purpose: The aim was to study the synergistic effects of the placental immunoregulation plypeptide (PIP) and chemotherapeutic drugs on growth of tumor cell. Methods: The combination of PIP and chemotherapeutic drugs affects S_(180) and K562 cell is vitro and the proliferation of S_(180) and K562 cell was observed. Meantimes, The effets on the tumor bearing mices, the weight of the tumor and the tubercles of the metastasis were observed. Results: The combination of PIP and chemotherapeutic drugs could inhibit obviously the proliferation of PIP of S_(180) and K562 cell in vitor.In the, it was also observed that when cyclophosphamide (CY) was used alone, the inhibitory rate and metastasis rate were 23. 7 % and 20% respectively. When the combination of PIP and CY was used, the inhibitory rate and metastasis rate were 58% and 6. 7% respectively. Conclusion: PIP shows obviously the synergistic effect and inhibiting effect on tumor cells when combined with chemotherapeutic drugs.

关 键 词：胎盘免疫调节肽 抗肿瘤作用 环磷酰胺 协同作用 

分 类 号：R979.5[医药卫生—药品]