王氏保赤丸对高脂血症模型动物的影响  

Effect of Wangshi Baochi Pill on hyperlipidemia model animal

作　　者：王爱云[1] 陆茵[1] 王兆龙 张志芬 吕兴祥[1] 陈文星[1] 

机构地区：[1]南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室,江苏南京210029 [2]南通精华制药股份有限公司,江苏南通226005

出　　处：《中成药》2010年第8期1308-1311,共4页Chinese Traditional Patent Medicine

基　　金：国家"十一五"科技支撑计划--中药产业区域发展及特色产品开发项目(2006BAI06A19)

摘　　要：目的:考察王氏保赤丸(大黄、黄连、川贝、制南星等)对高脂血症的影响。方法:采用小鼠急性高脂血症模型和家兔高脂血症模型,分别在造模前后用王氏保赤丸干预,检测动物血脂变化和对血流变的影响。结果:在小鼠急性高脂血症模型中,王氏保赤丸78、234、702mg/kg剂量组均能显著降低血清甘油三酯(TG)和极低密度脂蛋白(VLDL)水平;家兔高脂血症模型中,王氏保赤丸能显著降低高脂血症动物模型血清总胆固醇(TC)和低密度脂蛋白(LDL)水平及LDL/HDL(高密度脂蛋白)比值,还能有效降低家兔高脂模型动脉粥样硬化指数,降低全血黏度。结论:王氏保赤丸对治疗模型动物高脂血症具有明确的预防和治疗作用,还能改善血流变。AIM： To observe the effect of Wangshi Baochi Pill（Radix et Rhizoma Rhei,Rhizoma Coptidis,Bul-bus Fritillariae cirrhosae,Rhizoma Arisaematis preparatum,etc. ） on hyperlipidemia. METHODS： The mouse acute hyperlipidemia model and rabbit hyperlipidemia model were used. The blood lipid and hemorheological index were tested to measure the effect of Wangshi Baochi Pill on hyperlipidemia animal through administration before or after making models. RESULTS： Wangshi Baochi Pill could lower TG significantly at 78,234,702 mg/kg dosage in mouse acute hyperlipidemia model. It could lower TC,LDL,LDL/HDL,atherosclerotic index and whole blood viscosity in rabbit hyperlipidemia model. CONCLUSION： Wangshi Baochi Pill has preventive and therapeutical effect on hyperlipidemia. It also can improve hemorheology.

关 键 词：王氏保赤丸 高脂血症 小鼠 家兔 

分 类 号：R285.6[医药卫生—中药学]