复方伊维菌素乳液在山羊体内的药代动力学研究  

Study on Pharmacokinetics of Ivermectin Emulsion Compound in Goats

作　　者：姜晓文[1] 张春燕[1] 于文会[1] 徐利 

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030 [2]哈尔滨和平兽药有限公司,哈尔滨150039

出　　处：《中国畜牧兽医》2010年第8期169-171,共3页China Animal Husbandry & Veterinary Medicine

摘　　要：为了探讨复方伊维菌素乳液在动物体内的药物代谢,为兽医临床提供用药参考。试验选取7只山羊,每只山羊按0.1mL/kg(伊维菌素0.2mg/kg,阿苯达唑10mg/kg)剂量口服,给药后0.5、1、2、3、4、6、8、12、16、24、36、48、60h颈静脉采血5mL,分离血清,-20℃保存,用高效液相色谱仪检测样品血药浓度。试验结果表明,①伊维菌素在山羊体内的代谢情况为:0.5h,0.112151μg/mL;第1次达峰时间为4h,0.302702μg/mL;第2次达峰时间为16h,0.258284μg/mL;60h,0.011118μg/mL。②阿苯达唑在山羊体内的代谢情况为:0.5h,0.049285μg/mL;第1次达峰时间为8h,4.95283μg/mL;第2次达峰时间为16h,5.694551μg/mL;60h,0.06434μg/mL。复方伊维菌素中的伊维菌素和阿苯达唑在山羊体内代谢时间短,第60小时已达到很低的血药浓度。To investigate the pharmacokinetics of Ivermectin emulsion compound in vivo, and to provide the medical information for the veterinary clinical diagnosis, 7 goats as experimental models were selected, and each goat was given orally Ivermectin emulsion compound by dose of 0.1 mL/kg （Ivermectin 0.2 mg/kg, Albendazole 10 mg/kg）. Blood samples were respectively taken 5 mL from Jugular vein at 0.5, 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, 48 and 60 h after administration, then the serum were separated and stored at -20 ℃. High performance liquid chromatography （HPLC） method was used to detect serum drug level. The results showed that： ①The metabolism of Ivermectin in goat： the drug concentration was 0.112151 μg/mL after 0.5 h; the first peak time was 0.302702 μg/mL after 4 h, and the second peak time was both 0.258284 μg/mL after 16 h and 0.011118 μg/mL after 60 h. ②Albendazole metabolism in goats：the drug concentration was 0.049285 μg/mL after 0.5 h; the first peak time was 4.95283 μg/mL after 8 h, and the second peak time were both of 5.694551 μg/mL after 16 h and 0.06434 μg/mL after 60 h.The metabolized time of Ivermectin and Albendazole of Ivermectin emulsion compound in goat was very short, and the drug concentration in serum was not too low until 60 h.

关 键 词：山羊 药代动力学 伊维菌素 阿苯达唑 

分 类 号：S859.795[农业科学—临床兽医学]