胆石症病人的胆石成分与胆汁成分的相互关系  

RELATIONSHIP BETWEEN THE COMPOSITIONS OF GALLSTONE AND BILE

作　　者：童赛雄[1] 孟承伟[1] 林守诚[1] 

机构地区：[1]上海医科大学附属中山医院外科

出　　处：《上海医学》1990年第9期503-508,共6页Shanghai Medical Journal

摘　　要：本文对42例胆石症病人的胆石与胆汁的成分作了比较和分析。42例中,胆囊结石36例,其中胆固醇性结石(CS)27例,胆色素性结石(PS)9例。胆管结石6例均为PS。PS与CS相比,钙、镁、铜、铁的含量明显增高。CS病人的胆汁有明显高的胆固醇饱和度(LI=1.50)和CA/CDCA的比值上升。PS病人的胆汁有明显高的未结合胆红素。CA/CDCA的比值下降。钙的含量相似,铜、铁、镁的含量增加。胆石中胆固醇含量与胆汁中成石指数呈正相关(r=0.78),胆色素含量与胆汁中未结合胆红素含量呈正相关(r=0.63)。胆汁中胆固醇(x_1),磷脂(x_2)、胆汁酸(x_3)和未结合胆红素(x_4)与胆石中胆固醇含量(y)的相关回归方程为y=57.83+4.77x_1-1.36x_2-0.12x_3-0.28x_4。The composition of 27 cholesterol stones and 9 pigment stones from gallbladder, 6 pigment stones from hepatic duct and their surrounding bile were studied. Pigment stone contained significantly greater amount of metal elements such as Ca, Mg, Cu, Fe than cholesterol stone. Compared with the control group, bile surrounding cholesterol store had high lithogenic index (LI=1.50) and high CA/CDCA ratio. There was higher unconjugated bilirubin content in the bile surrounding pigment stones, and decreased ratio of CA/CDCA and increased amount of metal elements such as Mg, Cu and Fe, but amounts of calcium in bile of both groups were similar.The stone composition is highly related to that of the bile. The correlation regression equation is Y=57.83+4.77X_1-1.36X_2-0.12X_3-0.28X_4, where Y represents cholesterol content(%) in stone; X_1, cholesterol(mmol); X_2, phospholipid (mmol); X_3, bile salts in(mmol); and X_4, UCB (μmol) in bile.

关 键 词：胆结石 胆石成分 胆汁成分 

分 类 号：R657.420.2[医药卫生—外科学]