谷胱甘肽硫转移酶M1基因多态性与低出生体重的相关性  

Association of genetic polymorphisms of GSTM1 gene in mother with low birth weight of newborns

作　　者：付中秋[1] 刘心平[2] 

机构地区：[1]哈尔滨医科大学附属第二医院儿内科,150081 [2]哈尔滨医科大学生物化学教研室,150081

出　　处：《国际遗传学杂志》2010年第4期198-200,共3页International Journal of Genetics

基　　金：黑龙江省卫生厅基金（2009-133）

摘　　要：目的为探讨谷胱甘肽硫转移酶M1基因（glutathione S-transferases M1 gene，GSTM1）多态性与低出生体重的关系。方法采用病例对照研究方法，收集母亲和新生儿资料，用等位基因特异性PCR方法分析母亲GSTM1基因型。应用Logistic回归，对母体GSTM1基因与新生儿低出生体重的相关性进行分析。结果GSTM1缺失基因型对低出生体重影响未显示显著相关性[OR=1．553，95％C／（0．705．2．863）；OR=2．016，95％C／（10．961．2．942）]。结论 母亲GSTM1基因多态性与低出生体重无相关性。Objective To evaluate the association between maternal genetic polymorophisms of the glutathione S-transferases M1 gene （ GSTM1 ） and neonatal low birth weights. Methods Case-control study method was used, and data of mothers and infants were collected from medical record. Allele specific PCR method was applied to examine GSTM1 potymorphisms and logistic regression was used to analyze the association. Results No significant correlation was found between maternal polymorphisms of GSTM1 and neonatal low birth weight [OR = 1. 553, 95 %CI（0. 705 .2. 863）;OR =2. 016, 95 %CI（0.961 .2.942）, respectively]. Conclusion There is no significant correlation or association between maternal genetic polymorphisms of GSTM1 gene and neonatal low birth weight.

关 键 词：谷胱甘肽硫转移酶M1 多态性 基因 低出生体重 

分 类 号：R722[医药卫生—儿科]