豆腐果苷对慢性应激小鼠行为学的影响  

Effect of Helicid on the behavior in chronically stressed mice

作　　者：童九翠[1] 谢海棠[1] 杨斌[1] 陈艾东[1] 李海刚[1] 潘行山[1] 贾元威[1] 钟民[1] 江思艳[1] 

机构地区：[1]皖南医学院弋矶山医院安徽省药物临床评价中心

出　　处：《中国临床药理学与治疗学》2010年第6期641-645,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：安徽省高等学校省级自然科学研究基金(KJ2009B288Z)

摘　　要：目的:研究豆腐果苷对慢性应激抑郁小鼠行为学的影响。方法:连续28d给予小鼠慢性不可预见性的刺激与孤养,建立小鼠抑郁模型,同时给予豆腐果苷(40、20、10mg/kg,i.g.)或盐酸氟西汀(2.6mg/kg,i.g.),采用敞箱试验、蔗糖饮水实验及情绪性行为评分等观察豆腐果苷的抗抑郁行为效应。结果:豆腐果苷可逆转慢性应激小鼠自发活动减少,糖水偏爱度降低,情绪性行为评分及体重的降低。结论:豆腐果苷对慢性应激小鼠具有抗抑郁作用。AIM： To study the effect of Helicid on the behavior in chronically stressed mice. METHODS： Mice were exposed to chronic mild stress（CMS） and isolated breed for 28 consecutive days with coadministration of Helicid （40, 20,10mg/kg, i.g. ） orFluoxetine （2.6mg/kg, i. g.）. The open field test , sucrose preference test and emotional behavior score were applied to assess the behavior efficacy. RESULTS： Helicid or Fluoxetine treatment reversed depression-like behaviors such as deficient locomotory , reduced sucrose preference, emotional behavior score and weight. CONCLUSION： Helicid has an obvious ly antidepressant effect in chronically stressed mice.

关 键 词：豆腐果苷 抗抑郁药 慢性应激 行为 动物 

分 类 号：R965[医药卫生—药理学]