基于胃肠道生理模型的口服药物吸收预测  

Physiologically based gastrointestinal models for the prediction of oral drug absorption

作　　者：黎国富[1,2] 杨劲[1] 张雪莹[1] 赵浩如[1] 

机构地区：[1]中国药科大学药物代谢与药物动力学研究中心 [2]中国药科大学中药制剂教研室

出　　处：《中国临床药理学与治疗学》2010年第6期656-662,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：药物的口服吸收受到许多生理因素的影响,如胃肠液成分、pH、肠道内传输、转运和代谢等。在进行非临床和临床体内试验之前,如果仅仅依靠体外数据能够准确地预测药物的口服吸收,将会大大提高新药研发的效率。在深入理解口服吸收过程的基础上发展起来的胃肠道生理模型为从事新药研发的科研工作者提供了这种机会。这些生理模型可以与经典的药动学模型紧密衔接,用于预测药物的口服吸收速度和程度。本文综述了胃肠道生理模型的最新进展,并对不同的模型进行了比较和讨论。Oral drug absorption is influenced by different physiological factors,such as composition of gastrointestinal fluid,pH,transit,transport and metabolism.The ability to accurately predict the oral drug absorption only depended on in vitro results,before preclinical or clinical researches will improve the efficient of drug development.Various physiologically based gastrointestinal models based on the profound understanding of oral absorption process provide an opportunity to assess in vivo oral absorption.These physiological models can link to classical pharmacokinetic models to predict the rate and extent of oral drug absorption.This paper reviews the principle and new application of these physiological models,then compare and discuss with those.

关 键 词：胃肠道生理模型 生理药动学模型 高级房室吸收和传输(ACAT)模型 高级溶出、吸收和代谢(ADAM)模型 生物药剂学分类系统 

分 类 号：R969.1[医药卫生—药理学]