3-氧环丁羧酸的合成研究  

Improvements on the Synthesis of 3-Oxocyclobutanecarboxylic Acid

作　　者：黄斌[1] 张征林[2] 

机构地区：[1]东南大学成贤学院化工与制药工程系,江苏南京210088 [2]东南大学化学化工学院,江苏南京210088

出　　处：《精细化工中间体》2010年第4期31-33,共3页Fine Chemical Intermediates

摘　　要：以丙酮、甲醇、溴和丙二酸二酯为起始原料,经过溴化、环合、水解及脱酸合成了3-氧环丁羧酸,4步反应总收率44.07%。产品经1H NMR、元素分析和质谱表征。改进后的方法具有操作简单、成本低等优点,适合工业化生产。3-Oxocyclobutanecarboxylic acid was synthesized from methanol,acetone and bromine via bromination,cyclization,salification and hydrolysis in an overall yield of 44.07%.Structure of the product was confirmed by 1H NMR,elementary analysis and MS.This improved method is of many advantages,such as easy operation and low cost,which are feasible to large scale preparation.

关 键 词：3-氧环丁羧酸 环合 合成 

分 类 号：TQ225.13[化学工程—有机化工]