头孢克肟颗粒溶出度检查方法研究  

Study on dissolution for cefixime granules

作　　者：许世辉[1] 

机构地区：[1]安徽阜阳市药品检验所,阜阳236015

出　　处：《海峡药学》2010年第8期59-62,共4页Strait Pharmaceutical Journal

摘　　要：目的建立头孢克肟颗粒中主药溶出度的测定方法。方法采用紫外分光光度法,在288nm波长处测定头孢克肟颗粒中主药的吸收度,并计算回收率和溶出度。结果头孢克肟检测浓度线性范围为2.67～21.36μg·mL-1(r=0.9990);平均回收率为99.9%(RSD=0.70%,n=9);3批样品在45min溶出量均在75%以上。结论本方法准确、可靠,可用于该制剂的溶出度测定。OBJECTIVE To establish cefixime granules in the determination of the main method of drug dissolution.METHODS UV spectrophotometry was measured at 288nm wavelength of Cefixime Granules main drug absorption, and calculate the recovery and dissolution. RESULTS The concentration of cefixime in the linearrange of detection of 2.67--21.36μg·mL^-1（r= 0.9990）; The average recovery was 99.9% （RSD= 0.70%, n = 9）; 3 batches of samples in 45rain dissolution volume more than 75 % .CONCLUSION This method is accurate, reliable and can be used for determination of the dissolution of the preparation.

关 键 词：头抱克肟 溶出度 

分 类 号：R927.2[医药卫生—药学]