关苍枡乙酸乙酯提取物的抗炎作用实验研究  

Antiinflammatory action of extraction of atractylodes japonica by ethyl acetate

作　　者：陈晓光[1] 金正男[2] 黄红延 

机构地区：[1]青岛市人民医院肿瘤生物治疗中心,山东青岛266000 [2]延边大学医学院药理学教研室,吉林延吉133000

出　　处：《延边大学医学学报》1999年第2期106-110,共5页Journal of Medical Science Yanbian University

摘　　要：［ 目的］ 观察关苍枡乙酸乙酯提取物对急、慢性和免疫性炎症的作用，探讨其作用机理．［ 方法］ 利用动物模型．［ 结果］ 关苍枡乙酸乙酯提取物能明显地抑制二甲苯和巴豆油所致小鼠耳壳肿胀、角叉菜胶所致大鼠足肿胀、小鼠棉球肉芽肿增生及Ｆｒｅｕｎｄ’ｓ 完全佐剂所致大鼠关节炎．［ 结论］ 关苍枡乙酸乙酯提取物具有抑制急、慢性及免疫性炎症的作用．还可降低毛细血管通透性，增强小鼠单核巨噬细胞系统的吞噬功能，减少炎症部位的前列腺素Ｅ２ 含量。OBJECTIVE To study the effects of extraction of atractylodes japonica by ethyl acetate on acute, chronic and immune inflammation.METHOD Animal models were used.RESULT Extraction of atractylodes japonica by ethyl acetate inhibit several inflammatory processes such as edema induced by xylene and cronton oil in the ear of mice, proliferation of granulema induced by cotton pellets in mice, edema induced by carrageenin in the hind paw and arthritis induced by adjuvant in rats.CONCLUSION Extraction of atractylodes japonica by ethyl acetate has an inhibitory action for acute, chronic and immune inflammation. Also, extraction of atractylodes japonica by ethyl acetate inhibit capillary permeability, increas phagocytic function of the mononuclear phagocyte system in mice. In addition, extraction of atractylodes japonica by ethyl acetatedecreas the contents of prostaglandin E 2 in its inflammatory site, but increas the contents of serum superoxide dismutase.

关 键 词：炎症 关苍术 大鼠 小鼠 中药 药理 

分 类 号：R282.710.5[医药卫生—中药学]