血液透析及骨髓移植患者TT病毒感染情况分析  

Analysis of TTV infection in patients of hemodialysis and bone marrow transplantation

作　　者：林潮双[1,2] 黄仰苏[1,2] 陈文思[1,2] 陈幼明[1,2] 张宇锋[1,2] 廖家杰[1,2] 高志良[1,2] 

机构地区：[1]中山医科大学第三医院传染科 [2]香港大学医学院玛丽医院

出　　处：《中华实验和临床病毒学杂志》1999年第2期194-196,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：广东省自然科学基金

摘　　要：目的了解ＴＴ病毒（简称ＴＴＶ）在血液透析患者和骨髓移植患者中的感染情况，并评估ＴＴ病毒的致病力。方法回顾性调查３７例血液透析患者和９０例骨髓移植患者的ＴＴＶ感染情况，分析ＴＴＶ感染的致病力。结果ＴＴＶ在３７例血液透析患者中的感染率为１６２２％（６／３７），在９０例骨髓移植患者中的感染率为３３３％（３／９０），经统计学处理，两组感染率比较有显著性差异。６例ＴＴＶ阳性患者中５例有输血史，４例行肾移植术。ＴＴＶ感染与是否存在ＨＢＶ或ＨＣＶ感染无关。未发现ＴＴＶ阳性和ＴＴＶ阴性两组之间肝功能的损害程度存在差异。结论输血或血浆在传播ＴＴＶ感染上有重要意义。ＴＴＶ的致病力较弱。ＴＴＶ是否嗜肝病毒，有待进一步研究。Objective To make clear the infection of TT virus(TTV) in patients of hemodialysis and bone marrowtransplantation and to evaluate the virulence. Methods The TTV infection were investigated in 37 cases of hemodialysis and 90 cases of bone marrowtransplantation by means of review method. Results The positive rate of TTV was 16.22%(6/37) in 37 cases of hemodialysis and 3.33%(3/90) in 90 cases of bone marrowtransplantation. The difference between them was significant(P<0.01). Of the six TTVpositive patients, 5 had blood transfusion and 4 of them had bone marrowtransplantation. Infection of TTV had nothing to do with the infection of HBV and HCV. There were no significant differences in the results of liver function tests between TTV positive and TTV negative patients. Conclusion These results suggest that blood transfusion might be one of the critical routes to transmit TTV. The virulence of TTV might be mild. Whether TTV is a hepatitis viral remains further study.

关 键 词：血液透析 骨髓移植 TT病毒 致病力 

分 类 号：R459.5[医药卫生—治疗学]