生脉注射液与老年患者术后认知功能障碍的研究  

A study on influences of Shengmai injection on early postoperative cognitive dysfunction of older patients

作　　者：张序昊[1] 易斌[1] 罗春霞[2] 

机构地区：[1]第三军医大学西南医院手术麻醉科,重庆430038 [2]第三军医大学西南医院神经内科,重庆430038

出　　处：《重庆医学》2010年第17期2317-2318,共2页Chongqing medicine

摘　　要：目的探讨生脉注射液在降低老年患者术后认知功能障碍（POCD）发生率、减轻其发病程度中的作用。方法将92例65~80岁接受全髋关节置换术患者,ASAⅠ~Ⅱ级,按照术中是否使用了生脉注射液分为生脉注射液组（S组,44例）和对照组（C组,48例）。S组给予生脉注射液60 mL加入5%葡萄糖溶液240 mL静脉滴注;C组给予5%葡萄糖溶液300 mL静脉滴注。术后恢复期记录患者睁眼时间、拔管时间和应答时间,并于拔管后0.5、3、6、24 h分别进行简易智力状态检查（MMSE）评分。结果两组患者MMSE评分均有不同程度的下降,24 h后逐渐恢复;S组睁眼时间（15.8±4.2）min,短于C组（19.0±4.7）min;MMSE评分S组术后0.5、36、h分别为25.2±0.8、27.6±0.7、27.8±0.6,明显高于C组,差异有统计学意义（P〈0.05）。结论生脉注射液可降低老年手术患者早期POCD的发生率,并减轻其发病程度。Objective To determine the value of Shengmai injection used to decrease the rate and lighten the degree of postoperative cognitive dysfunction（POCD）.Methods Ninty-two ASA ⅠorⅡ patients aged 65-80 years old,undergene total hip replacement were divided into two groups：group S received Shengmai injection（44 patients） and group C（control group,48 patients） teceived 60 mL Shengmai injection and 240 mL 5%GS or 300 mL 5%GS respectively.The time of eye-open,extubation and verbalization was recorded during the recovery period.The mini-metal state examination（MMSE） was used to assess the cognitive function before and 0.5h,3h,6h,24 h after operation.Results Cognitive function of all patients was impaired after operation,and recovered at 24 h.The time of eye-open of group S was（15.8±4.2）min,less than group C（19.0±4.7）min.Group S′s MMSE scores of 0.5 h,3 h and 6 h（25.2±0.8）,（27.6±0.7）,（27.8±0.6） separately,which were raised obviously than group C（P〈0.05）.Conclusion Shengmai injection could decrease the rate of POCD and lighten the degree after the operation.

关 键 词：生脉注射液 简易智力状态检查 术后认知功能障碍 

分 类 号：R269[医药卫生—中西医结合]