低分子肝素对慢性肺心病顽固性心衰的疗效观察  

Clinical observation of low molecular weight heparin in the treatment of chronic cor pulmonale with obstinate heart failure

作　　者：范敏娟[1] 赵国厚[1] 袁开芬[1] 

机构地区：[1]昆明医学院第二附属医院干部医疗和老年呼吸病科,650101

出　　处：《中国老年保健医学》2010年第4期24-25,共2页Chinese Journal of Geriatric Care

摘　　要：目的观察低分子肝素对慢性肺心病顽固性心衰的治疗效果。方法慢性肺心病并发顽固性心衰患者57例,随机分为治疗组30例和对照组27例,两组均给予氧疗、抗感染、止咳平喘、改善心肺功能等常规治疗,治疗组在常规治疗的基础上加用低分子肝素钙,观察两组治疗前后临床疗效、体循环淤血情况的改善,以及动脉血气、肺动脉收缩压的变化。结果治疗组较对照组疗效显现更快,动脉血气、肺动脉收缩压、心肺功能明显改善,治疗组有效率达90%,对照组有效率66.7%,两组间有明显差异,P<0.05。结论对慢性肺心病急性加重期顽固性心衰患者,采用低分子肝素抗凝治疗是可选择的有效方法。Objective To explore the low molecular weight heparin in the treatment of obstinate heart failure of chronic cor pulmonale.Methods 57 patients with chronic cor pulmonale with obstinate heart failure were randomly divided into treatment group（n=30）and control group（n=27）,both groups were given routine treatment,such as oxygen therapy,anti-infection,suppressing cough and relieving dyspnea,improvement both in the heart function and lung function,the treatment group were given low molecular weight heparin calcium on the basis of routine treatment,then observed the clinical effect,the improvement of congestion of systemic circulation,and the change in artery blood gas analysis and pulmonary arterial systolic pressure.Results The appearance of the curative effect of the treatment group was faster than that of the control group;there was a significant improvement in artery blood gas analysis,pulmonary arterial systolic pressure,and the heart and lung functions.The effective rate of the treatment group and control group were 90% and 66.7%,respectively,and there were significant difference between the two groups（P0.05）.Conclusion For the patients with obstinate heart failure of chronic cor pulmonale in acute exacerbation,it was an optional effective method to use low molecular weight heparin in the treatment.

关 键 词：慢性肺心病 顽固性心衰 低分子肝素 

分 类 号：R541.5[医药卫生—心血管疾病]