综合性干预对代谢综合征患者血浆脑钠肽水平的影响  

Influence of brain natriuretic peptide by comprehensiveness intervention in patients with metabolic syndromes

作　　者：高美玲[1] 张雪娟[1] 

机构地区：[1]青岛大学医学院附属医院,266000

出　　处：《中国老年保健医学》2010年第4期90-91,共2页Chinese Journal of Geriatric Care

摘　　要：目的探讨综合性干预致代谢综合征患者生活方式改变和治疗依从性提高对血浆脑钠肽(N-proBNP)水平的影响及脑钠肽作为评价指标在综合性干预对代谢综合征患者治疗效果的意义。方法 50名MS患者随机分为对照组和综合干预组。对照组按常规进行治疗护理,综合干预组进行规范化的护理干预,使其学会健康的生活方式,使体重在第一年降低5%～10%,并遵医嘱按时用药治疗,观察两组患者治疗前后血浆脑钠肽水平的变化。结果与对照组相比,综合干预组干预前血浆N-proBNP水平无明显差异(t=1.64,P>0.05),综合干预后,综合干预组血浆N-proBNP明显降低(t=4.67,P<0.01)。与干预前比较,对照组及综合干预组干预治疗后血浆N-proBNP水平均有不同程度下降,差异有统计学意义(t=7.76～11.82,P<0.01)。结论综合性干预措施可使患者养成健康的生活方式,提高治疗的依从性,使脑钠肽水平明显下降,脑钠肽可作为评价综合性干预对代谢综合征治疗效果的指标。Objective To explore the influence of serum brain natriuretic peptide by comprehensiveness intervention in patients with metabolic syndromes （MS） and its significance as a index to evaluate the therapeutic efficacy of comprehensiveness intervention.Methods Fifty MS patients were randomly divided into control group and experiment group.The control group were treated with routine care while experiment group were treated with normalization intervention and develop a healthy life style so that weight in the first year was reduced by 5%～10% and patients of the two groups took medicine on time under supervision of a physician.Observe brain natriuretic peptide before and after treatment of two groups.Results There was no difference between control group and experiment group before intervention（t=1.64,P0.05）.But compare with control group,the level of N-proBNP decreased significantly（t=4.67,P0.01） after intervention.Compare with the level of N-proBNP,it decreased with different degree in both groups and the difference was significantly（t=7.76～11.82,P0.01）.Conclusion Comprehensiveness intervention can make patients develop a healthy life style,enhance treatment compliance and make brain natriuretic peptide decrease significantly,so that brain natriuretic peptide can act as a index to evaluate the therapeutic efficacy of comprehensiveness intervention on metabolic syndromes patients.

关 键 词：综合性干预 生活方式 代谢综合征 脑钠肽 

分 类 号：R473.5[医药卫生—护理学]