混合透皮促进剂对替硝唑凝胶透皮吸收作用的研究  

The effect of mixed transdermal enhancers on percutaneous absorption of tinidazole gel

作　　者：柏干荣[1] 罗波[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所第二研究室,重庆400042

出　　处：《中国医院药学杂志》1999年第7期390-392,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：考察混合促进剂月桂氮苷卓酮和薄荷脑对替硝唑透皮吸收作用的影响。方法：采用改良 Ｆｒａｎｚ 直立式释放池，以离体小白鼠皮肤为透皮屏障，使用不同浓度的混合月桂氮苷卓酮和薄荷脑，测量替硝唑的透皮吸收量。结果：含０ ．５ ％ ，１ ．５ ％ ，２ ％ ，２ ．５ ％ 月桂氮苷卓酮和薄荷脑的替硝唑凝胶与不含月桂氮苷卓酮和薄荷脑的替硝唑凝胶间，其透皮吸收在２４ ｈ 后有显著差异（ Ｐ＜ ０ ．０５） 。含１ ％ 月桂氮苷卓酮和薄荷脑的替硝唑凝胶与不含月桂氮苷卓酮和薄荷脑的替硝唑凝胶间，其透皮吸收在２ ｈ 后则呈极显著差异（ Ｐ＜ ０ ．０１） 。结论：不同浓度的混合促进剂均可不同程度地促进替硝唑的透皮吸收效果，其中以１ ％ 月桂氮苷卓酮加１ ％ 薄荷脑组成的混合促进剂作用最显著。OBJECTIVE:To observe the effect of mixed transdermal enhancers of azone and menthol on percutaneous absorption of tinidazole.METHODS:Using modified Franz type vertical diffusion cells and isolated mice skin in vitro as transdermal barrier,the transdermal amount of tinidazole in different concentrations mixed azone and menthol was determined.RESULTS:Comparison of tinidazole gel having no azone and menthol with the gels containg different azone and menthol concentrations of 0.5% , 1.5% ,2%, 2.5% showed a remarkable difference ( P < 0.05 ) after 2 hours. Comparison of tinidazole gel without azone and menthol with the gels containg 1% azone and menthol showed a remarkbal difference ( P < 0.01 ).CONCLUSIONS:It was demonstrated that various transdermal enhances could promote absorption of tinidazole in different level and 1% azone plus 1% menthol was the most effective one.

关 键 词：月桂氮Zhou酮 薄荷脑 替硝唑 透皮吸收 

分 类 号：R978.61[医药卫生—药品]