体外循环中猫心肌细胞膜微粘度的变化  

CHANGES IN MICROVISCOSITY OF FELINE MYOCARDIAL MEMBRANE DURING CARDIOPULMONARY BYPASS

作　　者：丁芳宝[1] 王志农[1] 张宝仁[1] 朱家麟[1] 陈晓东[1] 黄盛东[1] 朱泉芳[1] 

机构地区：[1]第二军医大学长海医院 [2]广州军区广州总医院

出　　处：《解放军医学杂志》1999年第3期185-186,共2页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金

摘　　要：应用荧光偏振法观察中度低温体外循环（ＣＰＢ）冷晶体停搏液间断顺灌和冷血停搏液持续顺灌组（Ｂ、Ｃ组）、常温ＣＰＢ温血停搏液持续顺灌组（Ｄ组）猫心肌细胞膜微粘度η的变化。结果表明，主动脉阻断期间和再灌注早期，各组η均显著增大，心肌细胞膜流动性显著减小；其中Ｂ组改变最大，Ｄ组最小且再灌注后期恢复最快。提示，３种方法中常温ＣＰＢ持续灌注温血停搏液对心肌的保护效果最佳，但仍须进一步改进。A fluorescence polarization technique was employed to determine the changes in microviscosity () of myocardial membrane of cats receiving antegrade intermittent cold crystalloid, continuous cold blood and continuous warm blood cardioplegia (groups B, C, D), respectively, during cardiopulmonary bypass (CPB). During aortic crossclamping and early reperfusion, in all groups increased significantly, and reached peak value at 1h after reperfusion, then it fell afterwards. increased most significantly in group B during CPB, least in group A. The results support the concept that further improvements on warm blood cardioplegia are still warranted despite of its affording greater myocardial protection than others.

关 键 词：体外循环 再灌注损伤 膜流动性 心肌缺血 猫 

分 类 号：R654.1[医药卫生—外科学] R364.12[医药卫生—临床医学]