过氧化物酶增生物-激活受体γ2基因多态性与2型糖尿病的相关性  

A population-based study of PPARγ2 gene polymorphism for type 2 diabetes

作　　者：高鹏[1] 吴江[2] 杜丹华[2] 张颖[2] 

机构地区：[1]吉林大学第一临床医院内分泌科,吉林长春130021 [2]吉林大学第一临床医院神经科,吉林长春130021

出　　处：《中国实验诊断学》2010年第8期1189-1191,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省卫生厅资助计划(项目编号:2008P008)

摘　　要：目的探讨PPARγ2基因多态性与2型糖尿病的关系。方法以rs1875796为遗传标记,应用多聚酶链-限制性片段长度多态性(PCR-RFLP)技术检测250例2型糖尿病患者和337例健康对照人群PPARγ2基因型。结果 Rs1875796基因型频率CC:CT:TT在2型糖尿病和正常对照组的频率分布分别为2.8%:27.2%:70.0%和2.7%:25.5%:71.8%;C等位基因和T等位基因在2型糖尿病组和正常对照组的频率分布分别为16.4%:83.6%和15.4%:84.6%,两组间的等位基因、基因型频率无显著差异(P>0.05)。结论 PPARγ2基因rs1875796多态性可能与2型糖尿病的发生无关。Objective To investigate file genetic association between the PPARγ gene polymorphism and type 2 diabetes. Methods 250 patients with type 2 diabetes were recruited into this study, and 337 healthy people were as controls. SNP rs1875796, a C to T base change located in intron 4 of the gene, was used as a genetic marker. PCR-based restriction fragment length polymoiphism analysis was applied to genotype rs1875796 （Hha I site）. Results The genotype frequencies（ CC： CT： TT） of rs1875796 in type 2 diabetes patients and control group were 2.8 % ： 27.2 % ： 70. 0 % and 2.7 % ： 25.5 % ： 71.8 %. Frequencies of C allele and T allele were 16.4 % ：83.6 % and 15.4 % ：84.6 %. The frequencies of allele and genotype distribution showed no significance between type 2 dia- betes patients and controls. Conclusion The present study suggests that the PPAR7 gene rs1875796 polymorphism is unlikely to con- tribute to the etiology of type 2 diabetes in Chinese Han.

关 键 词：糖尿病 过氧化物酶增生物-激活受体γ2 单核苷酸多态性 

分 类 号：R587.1[医药卫生—内分泌]