甲状腺自身抗体定量检测的临床应用  

The clinical application of quantitative analyse of thyroid autoantibodies in serum

作　　者：王旭[1] 张会英[1] 

机构地区：[1]北京积水潭医院检验科,北京100035

出　　处：《中国实验诊断学》2010年第8期1249-1251,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清中3种甲状腺自身抗体定量检测,在甲状腺疾病诊治中的价值。方法收集2009-2010年于我院门诊就诊及住院的甲状腺疾病患者238例,通过患者的病史、症状、体征及相关的辅助检查将患者分组。分别检测患病组及正常对照组血清中TPOAb、TGAb、TRAb浓度,观察3个抗体水平在不同疾病中的变化情况。结果不同疾病组及正常对照组血清中TPOAb、TGAb浓度水平差异具有统计学意义,其中桥本病、Graves’病组,血清中两种抗体水平与其他各组比较差异具有统计学意义,且桥本病患者血清中两种抗体水平明显高于其他三组;Graves’病发作组的TRAb阳性率及血清浓度水平均明显高于正常对照组,而Graves’病缓解组TRAb阳性率及测定值明显低于发作组。结论 TPOAb、TGAb在桥本病致病中起重要作用,而TRAb对于Graves’病有较高的诊断价值,可以作为诊断Graves’病的特异性指标,但与Graves’病的病情轻重无关。Objective To evaluate the clinical values of quantitative analyses of three kinds of thyroid autoantibodies in sertun. Methods 238 cases of outpatients and inpatients with thyroid diseases were collected from 2009 to 2010 , divided into 3 groups according to their clinical dams. Senun anti-thyroperoxidase antibody（TPOAb）, anti-thyroglobulin antibody（TGAb） and thyrotropin receptor antibody（TRAb） levels of disease groups and control group were assayed respectively, in order to investigate the changes of 3 antibodies in different thyroid diseases. Results The differences of the serum TPOAb and TGAb levels were statistically significant. The sermn levels of TPOAb and TGAb with Hashimoto＇ s thyroiditis were significantly higher than other groups, followed by the cases with Graves＇ disease. The level and positive rate of TRAb in serum were significantly higher in patiems with Graves＇ disease （ stage of attack） than the control group . The remission group with Graves＇ disease was significantly lower than it. Conclusion TPOAb and TGAb measurements are helpful in the diagnosis of Hashimoto＇ s thyroiditis . TRAb is also useful to detennin the Graves＇ disease, but can not reflect the thyroid function.

关 键 词：抗甲状腺过氧化物酶抗体 抗甲状腺球蛋白抗体 促甲状腺激素受体抗体 甲状腺疾病 

分 类 号：R581.1[医药卫生—内分泌]