S/O/W法制备PLGA/TiO_2载药微球  

PLGA/TiO2 drug loaded microsphere prepared with S/O/W method

作　　者：蔡静[1,2] 王超宝[1,2] 杨亚楠[1] 陈学思[2] 

机构地区：[1]长春工业大学合成树脂与特种纤维教育部工程研究中心,吉林长春130012 [2]中国科学院长春应用化学研究所生态环境高分子材料实验室,吉林长春130022

出　　处：《长春工业大学学报》2010年第3期245-250,共6页Journal of Changchun University of Technology

基　　金：吉林省科技厅科技计划基金资助项目(20080551)

摘　　要：将纳米TiO2吸附溶液中的BSA由水包油包固体乳化法用PLGA包裹药物粒子。通过紫外和SEM等检测手段,考察纳米TiO2在不同条件下对BSA吸附率的影响,以及不同制备工艺下PLGA包裹药物粒子对载药量和包封率及体外释放的影响。研究结果表明,当溶液的pH值接近蛋白质等电点、温度在20℃左右、反应24 h时,TiO2吸附BSA量最大,药物粒子分布均匀,尺寸在40 nm左右。在制备微球时,当初乳体积降低、PVA浓度降低及PLGA与药物粉末的质量比增大时,载药量和包封率都有提高,且微球体外释放较小。微球表面光滑,尺寸为4μm左右。BSA from nano-TiO2 absorbing solution is coated with PLGA via S/O/W method.Using UV-Vis and TEM,the impacts of nano-TiO2 on the BSA absorbing rate under different conditions and influence of PLGA coated drug particles on coating rate and the in-vitro-release are studied.The results show that the largest BSA absorbing on the TiO2 occurs with the conditions： pH is near the isoelectric point of BSA,temperature 20 ℃,incubation time 24 h.The drug article size is even with 40 nm diameter.When the microspheres are prepared,both the drug loaded quantity and coated rate are improved when the volume of primary emulsion and PVA concentration decrease and quality rate of drug powders increase.The 4 μm-diameter microspheres,with smooth surface have small in-vitro-release.

关 键 词：S/O/W TIO2 PLGA 载药微球 纳米吸附 

分 类 号：TQ460.4[化学工程—制药化工]