复方甲硝唑药膜的制备及含量测定  

Preparation and quality control of Compound Metronidazole Membrane

作　　者：周晓虹[1] 

机构地区：[1]广州市第一人民医院药剂科,广东广州510180

出　　处：《中国医药导报》2010年第24期46-47,共2页China Medical Herald

摘　　要：目的:研究复方甲硝唑药膜的制备及含量测定的方法。方法:采用聚乙烯醇(PVA124)及羧甲基纤维素钠(CMC-Na)等高分子有机材料制备复方甲硝唑药膜,并采用双波长紫外分光光度法测定复方甲硝唑药膜的含量,甲硝唑测定波长为319nm,醋酸氯己定的测定波长为230nm,参比波长为350nm。结果:甲硝唑在5～25μg/ml浓度范围内呈良好线性关系,醋酸氯己定在2～10μg/ml浓度范围内呈良好线性关系,平均回收率分别为99.8%和99.6%,相对误差均为0.2%。结论:复方甲硝唑药膜制备方法简单,重现性好,紫外含量测定结果准确可靠。Objective：To study the preparation and quality control of Compound Metronidazole Membrane.Methods：Preparation compound metronidazole membrane used by organic polymer materials such as polyvinyl alcohol（PVA124） and sodium carboxymethyl cellulose（CMC-Na）.Using dual-wavelength UV Spectrophotometric determination of compound metronidazole film content.Determination of metronidazole wavelength was 319 nm.Determination of chlorhexidine acetate wavelength was 230 nm,the reference wavelength was 350 nm.Results：The standard curve of metronidazole was linear within a concentration range of 5-25 μg/ml,the standard curve of chlorhexidine acetate was linear within a concentration range of 2-10 μg/ml,the average recovery was 99.8% and 99.6%,relative error was all 0.2%.Conclusion：The preparation of the compound metronidazole film is simple,reproducible,and its method of UV measurements is accurate and reliable.

关 键 词：甲硝唑 醋酸氯己定 口腔药膜 双波长分光光度法 

分 类 号：R927.2[医药卫生—药学]