凯时联合弥可保治疗对糖尿病心脏自主神经病变患者心率变异性的影响  

The influence of Alprostadil Injection combined Methylcobalamin treatment of diabetic cardiac autonomic neuropathy in patients with heart rate variability

作　　者：刘伟芳[1] 施丽芳[1] 

机构地区：[1]广东省惠州市中心人民医院内分泌科,广东惠州516001

出　　处：《中国医药导报》2010年第24期50-52,共3页China Medical Herald

摘　　要：目的:评价凯时联合弥可保治疗对糖尿病心脏自主神经病变患者心率变异性的影响。方法:收集糖尿病合并心脏自主神经病变患者88例,分为治疗组(n=44)和对照组(n=44),治疗组患者给予凯时10μg加生理盐水10ml联合弥可保0.5mg加生理盐水10ml,静注,每日1次,总疗程3周。对照组给予肌注维生素B1和维生素B12,每日1次。运用24h动态心电图检测所有患者治疗前后心率变异性指标,观察治疗前后上述指标的变化,并进行对比分析。结果:治疗组治疗后心率变异性各项指标较治疗前有显著提高,自主神经病变症状明显好转,与对照组比较,差异有统计学意义(P<0.01或P<0.05)。结论:凯时联合弥可保治疗糖尿病心脏自主神经病变的疗效显著,可以改善患者心率变异性。Objective：To evaluate the influence of Alprostadil Injection combined Methylcobalamin treatment of diabetic cardiac autonomic neuropathy in patients with heart rate variability.Methods：88 patients of diabetic cardiac autonomic neuropathy were divided into treatment group（n=44） and control group（n=44）,the treatment group were treated with saline 10 ml plus Alprostadil Injection 10 μg and saline 10 ml plus Methylcobalamin 0.5 mg intravenously once a day,with a total course of treatment for 3 weeks.Control group injected vitamin B1 and vitamin B12,once a day.Used 24-hour ambulatory ECG testing before and after treatment in all patients of heart rate variability index,observed and analyzed changes in these indicators before and after treatment.Results：After treatment,the heart rate variability index was significantly increased compared with before treatment,and autonomic neuropathy symptoms improved,compared with the control group,the differences was statically significant（P0.01 or P0.05）.Conclusion：Alprostadil Injection combined Methylcobalamin treatment of diabetic cardiac autonomic neuropathy has significant effect and can improve heart rate variability.

关 键 词：凯时 弥可保 糖尿病 心脏自主神经病变 心率变异性 

分 类 号：R587.2[医药卫生—内分泌]