复原再生汤对大鼠周围神经损伤后修复的作用  

Promoting Effects of Fu Yuan Zai Sheng Decoction on Regeneration and Repairation of Injured Peripheral Nerves

作　　者：曹希勤[1] 刁凤声[1] 田迪[1] 

机构地区：[1]大连医科大学附属第二医院中医康复科,辽宁大连116027

出　　处：《中国康复》2010年第4期250-252,共3页Chinese Journal of Rehabilitation

摘　　要：目的:观察复原再生汤对大鼠周围神经损伤的再生作用。方法:Wistar大鼠60只,采用钳夹左侧坐骨神经建立周围神经损伤模型,随机分为3组各20只,分别用复原再生汤(F组)、甲钴胺加VitB1(M组)及生理盐水(K组)灌胃。给药4周后进行坐骨神经功能指数(SFI)、神经电生理学、肌肉及神经组织形态学的检测。结果:给药4周后,F组大鼠SFI指数、神经传导速度及复合肌肉诱发电位振幅及小腿三头肌湿重、肌细胞截面积、有髓神经轴突计数等恢复率均显著优于M组及K组,M组优于K组(均P<0.05)。结论:复原再生汤可促进大鼠周围神经损伤早期的修复、再生和功能的恢复。Objective：To investigate the promoting mechanism of Fu Yuan Zai Sheng decoction （FYZSD） on regeneration and repairation of the injured peripheral nerves. Methods：Peripheral nerve injury models were set up by crushing the right sciatic nerves in 60 model Wistar rats,and the rats were randomly divided into experimental group （FYZSD）,methylcobalamin and vitamin B1 group,and control group （normal saline）. Then sciatic nerve functional index （SFI）,electrophysciological indexes,muscle and histomorphological indexes were tested. Results：The recovery rate of SFI was statistically significantly higher in the experimental group than in the other two groups at the fourth week. For electrophysciological indexes,nerve conduction velocity and amplitude of compound muscle evoked potential recovery rate in the experimental group were significantly increased as compared with the other two groups. For muscle and histomorphological indexes,the wet weight of triceps muscle of calf,muscle cell cross-sectional area and myelinated nerve axon count recovery rate in the experimental group were significantly increased as compared with the other two groups. Conclusion：FYZSD can promote rat peripheral nerve injury repair and regeneration,and functional recovery in the early stage.

关 键 词：复原再生汤 周围神经损伤 大鼠 

分 类 号：R285.5[医药卫生—中药学]