萘丁美酮合成的改进  

Technological Improvement of Synthesis for Nabumetone

作　　者：陈小全[1] 左之利[2] 仇玉芹[3] 周秀艳[4] 张昌军[1] 翟虎[1] 邵辉莹[1] 李保庆[1] 

机构地区：[1]泰山医学院化学与化学工程学院,泰安271000 [2]中国科学院上海药物研究所,上海201203 [3]华东师范大学图书馆,上海200062 [4]四川大学化工学院,成都610065

出　　处：《有机化学》2010年第7期1069-1071,共3页Chinese Journal of Organic Chemistry

摘　　要：探讨合成萘丁美酮的新方法.以2-甲氧基萘为原料,在超声波作用下并使用新型催化剂合成萘丁美酮.所合成目标化合物经过IR,MS,1HNMR谱确证.通过与文献报道路线的对比,在超声波作用下合成此药物反应时间由原先的13.5h缩短到7.5h,产率由23.9%提高到39.4%.此法在合成萘丁美酮时,能够使合成时间缩短且产率提高.In order to explore new method for synthesis of nabumetone, a synthetic method was investigated by the treatment of 2-methoxy naphthalene under ultrasonic irradiation. The time of the new synthesis method would be shortened from 13.5 h to 7.5 h and yield would be increased from 23.9% to 39.4%. The structure of the synthetic compound was identified by IR, MS and 1H NMR techniques.

关 键 词：合成 萘丁美酮 超声波 改进 

分 类 号：TQ463.2[化学工程—制药化工]