四川地区结核分枝杆菌耐药性和耐药谱分析  

STUDIES ON DRUG RESISTANCE AND DRUG RESISTANT SPECTRUM OF MYCOBACTERIUM TUBERCULOSIS IN SICHUAN AREA

作　　者：陈建[1] 杨光京[2] 罗槑 

机构地区：[1]成都医学院,成都610041 [2]四川省结核病防治所 [3]成都结核病防治院检验科

出　　处：《现代预防医学》2010年第17期3211-3212,共2页Modern Preventive Medicine

基　　金：四川省教育厅科研基金课题资助(07ZC010)

摘　　要：[目的]探讨四川地区结核患者的耐药状况和耐药谱,为耐药结核的监测提供参考依据。[方法]对结核患者的临床分离株进行菌种鉴定,对鉴定为结核分枝杆菌的临床分离株进行药物敏感检测,并分析其耐药性和耐药谱。[结果]结核分枝杆菌的总耐药率为30.37%(99/326),不同性别、不同地区以及初治与复治结核患者携带菌株的耐药率存在统计学差异,对异烟肼(INH)、利福平(RIF)、链霉素(SM)和乙胺丁醇(EMB)的耐药率分别为15.64%(51/326)、15.03%(49/326)、9.51%(31/326)和6.13%(20/326)。[结论]四川地区结核患者耐药状况仍然严重,应进一步加强耐药结核的监测。[Objective] To explore drug resistance status and drug resistant spectrum of patients with tuberculosis in Sichuan areas and to provide evidence for the drug resistance surveillance of tuberculosis. [Methods] The clinical isolates of patients with tuberculosis were identified, in which Mycobacterium tuberculosis were detected by test of drug sensitivity and the drug resistance and drug resistant spectrum were analyzed. [Results] The total rate of drug resistance of Mycobacterium tuberculosis was 30.37% （99 / 326） and rates of drug resistance had statistical difference in different ages, different areas and between new patients and re-treat patients. The rates of drug resistance were respectively 15.64% （51 / 326）, 15.03% （49 / 326）, 9.51% （31 / 326） and 6.13% （20 / 326） to isoniazid, rifampicin, streptomycin and ethambutol. [Conclusion] The drug resistant status is still serious in Sichuan area and we should further strengthen on surveillance of drug resistant tuberculosis.

关 键 词：结核 耐药率 耐药谱 监测 

分 类 号：R378.911[医药卫生—病原生物学]