当归多糖对实验性糖尿病大鼠糖代谢的影响及其机制  

On Effects and Mechanism of Angelica Sinensis Polysaccharides on Glucose Metabolism in Experimental Diabetic Rats

作　　者：陈洁[1] 

机构地区：[1]武汉职业技术学院生物工程学院,湖北武汉430074

出　　处：《武汉职业技术学院学报》2010年第3期93-95,共3页Journal of Wuhan Polytechnic

基　　金：武汉职业技术学院2008年立项科研课题"当归多糖的分离;纯化与鉴定及其对肝损伤的干预作用"(项目编号:2008YK267)

摘　　要：研究当归多糖(ASP)对实验性糖尿病大鼠糖代谢的影响,探讨ASP对实验性糖尿病大鼠的降糖机制。制备实验性糖尿病大鼠40只,随机分成4组,分别用生理盐水、低剂量ASP(20mg.kg-1)、高剂量ASP(100mg.kg-1)以及盐酸二甲双胍(150mg.kg-1)灌胃给药,每日1次,连续21天。同时采用正常大鼠为健康对照,观察ASP对实验性糖尿病大鼠空腹血糖、血浆胰岛素、胰岛素敏感性指数、肝糖原等指标的影响。发现ASP能明显的降低糖尿病大鼠的血糖,其机制可能与其促进胰岛B细胞修复和再生有关,提示ASP有作为口服降糖药辅助用药的可能性。the paper presents the research on the effects of Angelica Sinensis Polysaccharides（ASP） on glucose metabolism in experimental diabetic rats,which leads to the finding of the mechanism of hypoglycaemic effect of ASP.Treated with ASP,FPG was reduced and Ins and hepatin were increased,respectively,as compared with model group.Conclusion ASP can obviously lower blood sugar,which may be associated with the promoting the repair and regeneration of the damaged islet B cell.The results suggest that ASP has the possibility to be used as an adjuvant drug of oral hypoglycemic agents.

关 键 词：当归多糖 四氧嘧啶 糖代谢 

分 类 号：R349.64[医药卫生—基础医学]