幽门螺杆菌感染与新疆地区原发性胃淋巴瘤的相关性研究  

Helicobacter Pylori infection and the primary gastric lymphoma in Xinjiang

作　　者：王路祎[1] 孙振柱[1] 

机构地区：[1]新疆医科大学基础医学院病理学教研室,新疆乌鲁木齐830011

出　　处：《公共卫生与临床医学》2010年第2期117-121,共5页Public health and dinical medicine

摘　　要：目的探讨幽门螺杆菌（HP）感染与新疆地区原发性胃淋巴瘤（PGL）的关系。方法观察49例原发性胃淋巴瘤的组织形态，并用免疫组织化学Envision二步法对其进行CD20，CD79a，CD3，CD45RO标记。分别采用幽门螺杆菌抗体（抗HP）和亚甲蓝对胃淋巴瘤组织切片进行HP染色。并选择42例慢性活动性胃炎做对照。结果49例胃淋巴瘤依据组织形态分为MALT淋巴瘤22例，非MALT淋巴瘤27例，抗HP阳性率分别为40％和12．5％，差异有统计学意义（P〈0．05）；亚甲蓝染色阳性率分别为30％和12．5％，差异无统计学意义（P〉0．05）。HP感染与性别、年龄、民族无明显相关性（P〉0．05），两种染色方法之间差异无统计学意义（P〉0．05）。结论幽门螺杆菌感染与新疆原发性胃MALT淋巴瘤之间有一定的相关性，新疆地区原发性胃淋巴瘤中幽门螺杆菌的阳性率偏低，免疫组化法和亚甲蓝染色法检测HP感染无差别。Objectives To investigate the association between Helicobacter pylori （HP） infection and primary gastric lymphoma （PGL） in Xinjiang. Methods The pathologic features of 49 cases of PGL were studied along with immunohistochemical study of antibodies including CD20, CD79a, CD3, CD45RO. HP was stained with anti-HP and methylene blue. 42 cases of chronic activated gastritis were enrolled as a control. Results Out of 49 cases, 22 cases were MALT lymphoma and 27 cases as non-MALT lymphoma, The anti-HP positive rate is 40 % and 12.5%, respectively, with a statistical significance （P〈0.05）; the methylene blue positive rate is 30% and 12.5%, respectively, with no statistical significance （P〉0.05）. HP infection has irrelevant to gender, age, and nationality. The difference of two stain methods is not significant （P〉0.05）. Conclusions There is weak associaion between HP infection and the primary gastric lymphoma in Xinjiang. The HP positive rate in primary gastric lymphoma in Xinjiang is low. Detections of the HP infection by immunohistochemistry or methylene blue have not reached significant difference.

关 键 词：幽门螺杆菌 胃淋巴瘤 

分 类 号：R517.9[医药卫生—内科学] R735.2[医药卫生—临床医学]