益气活血药对腹主动脉结扎术后早期心功能不全大鼠血流动力学的干预作用研究  

Reserch of Supplementing Qi and Activating Blood Circulation Herbs on Hemodynamics of Rats with Heart Failure Induced by Abdominal Aorta Ligation

作　　者：姜浩[1] 农一兵[1] 林谦[1] 

机构地区：[1]北京中医药大学

出　　处：《中西医结合心脑血管病杂志》2010年第8期948-950,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然基金资助项目(No.30701075)

摘　　要：目的研究丹参等活血药对心功能不全大鼠的血流动力学的干预作用。方法腹主动脉结扎造模术后的SD大鼠,随机分为假手术组(正常组)、模型组、中药组、西药组、中西医结合组。模型组和正常组给予生理盐水灌服。中药组给予活血药浸膏,西药组给予卡托普利,中西医结合组给予中药联合卡托普利片灌胃,治疗4周和8周后检测血流动力学。包括左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室内压上升下降最大速率(±dp/dtmax)、心率(HR)、外周平均动脉压(MBP)等。结果中药和卡托普利干预治疗4周后,中西医结合组LVSP、LVEDP明显低于模型组(P<0.05或P<0.01),而舒张末期最大下降速率(-dp/dt)明显高于模型组(P<0.01)。中西医结合组治疗8周后LVEDP明显低于模型组((P<0.01);而+dp/dtmax、-dp/dtmax明显高于模型组(P<0.01)。结论丹参等活血药方与西药卡托普利的联合使用能显著改善心功能不全大鼠的血流动力学,从而对心脏具有一定的保护作用。Objective To study the therapeutic effect of supplementing Qi and activating blood circulation herbs on hemodynamics in rats with chronical heart failure.Methods The Sprague-Dawley rats with abdominal aorta ligation were divided into 5 groups：Sham-operated group（normal group）given by normal saline,model group given by normal saline,herbs group treated by supplementing Qi and activating blood circulation herbs,captopril group treated by captopril,herbs-captopril group treated by supplementing Qi and activating blood circulation herbs and captopril.Left ventricular systolic pressure（LVSP）,left ventricular end diastolic pressure（LVEDP）,heart rate,peripheral mean arterial blood pressure（MBP）,maximal rise/fall rate of ventricular pressure（±dp/dtmax）were measured after four and eight weeks.Results After 4 weeks of treatment,LVSP and LVEDP in herbs-captopril group were significantly lower than that in model group（P0.05 or P0.01）.The ±dp/dtmax was higher than that in model group（P0.01）.After 4 weeks of treatment,LVEDP in herbs-captopril group were significantly lower than that in model group（P0.01）.The ±dp/dtmax was higher than that in model group（P0.01）.Conclusion The salvia miltiorrhiza and other blood circulation herbs combined with captopril could improve cardiac hemodynamic dysfunction in rats with chronical heart failure.

关 键 词：益气活血 心功能不全 血流动力学 大鼠 

分 类 号：R285.5[医药卫生—中药学]