芍药苷稳定性研究  

Study on stability of paeoniflorin

作　　者：解江纯[1] 刘志东[1] 田慧[1] 王颖[1] 

机构地区：[1]天津中医药大学现代中药发现与制剂技术教育部工程研究中心,天津300193

出　　处：《天津中医药》2010年第4期344-345,共2页Tianjin Journal of Traditional Chinese Medicine

基　　金：国际科技合作计划项目(2007DFC31670);国家科技支撑计划项目(2007BAI47B01);国家科技重大专项(2009ZX09311-002)

摘　　要：[目的]研究芍药苷在不同温度及pH条件下的稳定性。[方法]采用高效液相色谱法在不同温度及pH条件下,测定芍药苷在不同时间的含量变化。[结果]芍药苷在pH=9.0条件下,高于60℃在3h完全降解,在酸性条件下不降解。[结论]芍药苷在酸性条件下稳定,在碱性条件下随温度的升高,降解加速。[Objective] To investigate the stability of paeoniflorin in different pH and temperature.[Methods] The changes of paeoniflorin after placed for some time were determined by HPLC in different temperature and pH values.[Results] Paeoniflorin was completely degradated after placing at pH 9.0 or above a temperature of 60℃ for 3 h.No degradation was found in acid conditions.[Conclusion] paeoniflorin was stable in acid medium and degradation was accelerated when temperature increased or in a basic condition.

关 键 词：芍药苷 温度 PH 稳定性 

分 类 号：R284[医药卫生—中药学]