老年2型糖尿病患者臂踝脉搏波速度与微量白蛋白尿的关系  

Relationship between brachial-ankle pulse wave velocity and microalbuminuria in older patients with type 2 diabetes

作　　者：李明阳[1] 刘波[1] 刘丽芳[1] 

机构地区：[1]空军总医院干部病房,北京100142

出　　处：《中华保健医学杂志》2010年第4期285-287,共3页Chinese Journal of Health Care and Medicine

摘　　要：目的评价老年2型糖尿病患者臂踝脉搏波速度(baPWV)与尿微量白蛋白的关系及其临床意义。方法连续入选87例老年2型糖尿病患者,测量baPWV、血压,测定血糖、血脂、糖化血红蛋白(HbA1c)、肌酐及尿微量白蛋白值。根据尿白蛋白/肌酐比值(ACR)是否异常分为尿微量白蛋白正常组和尿微量白蛋白异常组。结果两组比较,尿微量白蛋白异常组baPWV较快,收缩压和脉压、HbA1c、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平均高于尿微量白蛋白正常组,差异有统计学意义(P<0.001)。多元逐步回归分析显示,收缩压、年龄、ACR是影响baPWV的独立危险因素,其标准化回归系数分别为:收缩压0.497,t=5.266,P<0.001,年龄0.265,t=3.292,P=0.002,ACR0.248,t=2.649,P=0.009。结论除收缩压和年龄外,尿微量白蛋白是影响baPWV的独立危险因素,这种影响可能和血压、血糖及血脂水平有关。Objective To observe the relationship between brachial-ankle pulse wave velocity（baPWV）and microalbuminuria as well as clinical significance in older patients with type 2 diabetes.Methods The baPWV,blood pressure,microalbuminuria and blood biochemistry test were measured in 87 consecutive older patients with type 2 diabetes.The patients were divided into two groups：normal microalbuminuria group and abnormal microalbuminuria group.Results Compared with normal microalbuminuria group,the abnormal microalbuminuria group had higher baPWV,higher systolic blood pressure（SBP）and pules pressure,and higher levels of HbA1c、TC and LDL-C.The difference was significant（P〈0.001）.In multiple stepwise regression analysis,the significant predictors of baPWV were SBP,age and microalbuminuria.The standardized coefficients were individually：SBP 0.497 t=5.266 P 0.001,age 0.265 t=3.292 P=0.002,microalbuminuria 0.248 t=2.649 P=0.009.Conclusions Except SBP and age,microalbuminuria was an independent predictor of baPWV.The effect maybe related to levels of SBP,glucose and blood lipids.

关 键 词：糖尿病 臂踝脉搏波速度 微量白蛋白尿 老年 

分 类 号：R587.1[医药卫生—内分泌]