纳洛酮+醒脑静联合无创机械通气治疗慢性阻塞性肺疾病合并肺性脑病  

Effect of naloxone and xingnaojing associated with BiPAP non invasive positive pressure ventilation (NIPPV) on chronic obstructive pulmonary disease (COPD) with pulmonary encephalopathy

作　　者：谭辉[1] 谭勤芳[1] 陈碧[1] 

机构地区：[1]郴州市第一人民医院中心医院,湖南郴州423000

出　　处：《实用药物与临床》2010年第4期255-256,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨纳洛酮+醒脑静联合无创机械通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)合并肺性脑病的疗效。方法将COPD合并肺性脑病的患者30例分为治疗组和对照组,两组患者均接受吸氧、无创机械通气、抗感染、解痉、平喘、止咳、化痰、纠正酸碱平衡、营养支持疗法,治疗组在此基础上,加用0.9%氯化钠溶液100mL+醒脑静20mL静脉滴注,2次/d;0.9%氯化钠溶液100mL+纳洛酮2mg静脉滴注,2次/d。平均疗程为(11.7±7.43)d。评估其疗效,并观察不良反应发生情况。结果治疗组PaCO2、PaO2明显改善(P<0.05),气管插管率、住院时间较对照组均明显降低(P<0.05)。结论纳洛酮+醒脑静联合无创机械通气可改善COPD合并肺性脑病患者的PaCO2、PaO2,明显缩短患者住院时间(P<0.05),降低气管插管率及病死率(P>0.05)。Objective To evaluate the effect of naloxone ＋ xingnaojing associated with non invasive positive pressure ventilation（ NIPPV） on COPD with pulmonary encephalopathy. Methods 30 patients of COPD with pulmonary encephalopathy were divided into therapy group and control group randomly. They were treated with low flow O2 inhale, NIPPV antibiotics,eliminate sputum and spasm,antiasthma,cough relieving,correct acetic-alkali equilibrium,nutritional support. The treatment group was also given NS 100 mL ＋ xingnaojing 20 mL iv,bid; NS 100 mL ＋ naloxone 2 mg iv bid. The average course was（ 11. 7 ± 7. 43） d,the therapeutic effect and adverse reaction were observed. Results In treatment group,the PaCO2 and PaO2 were improved（ P 0. 05） ,the rate of tracheal cannula and hospital stay were significantly shorter than those of control group（ P 0. 05） . Conclusion Naloxone ＋ xingnaojing associated with NIPPV is an effective therapeutic method in treating patients with COPD with pulmonary encephalopathy.

关 键 词：纳洛酮 醒脑静 无创机械通气 

分 类 号：R563.9[医药卫生—呼吸系统] R747.9[医药卫生—内科学]